PMID- 24968543
OWN - NLM
STAT- MEDLINE
DCOM- 20140728
LR  - 20140627
IS  - 0004-5772 (Print)
IS  - 0004-5772 (Linking)
VI  - 61
IP  - 12
DP  - 2013 Dec
TI  - Randomised controlled trial for efficacy of unfractionated heparin (UFH) versus 
      low molecular weight heparin (LMWH) in thrombo-prophylaxis.
PG  - 882-6
AB  - OBJECTIVE: To study if low dose Unfractionated heparin (UFH) is as effective and 
      safe as Low-molecular weight heparin (LMWH) and also economical as a prophylactic 
      agent for venous thromboembolism in medically ill patients. METHODOLOGY: A 
      prospective double blind randomised controlled trial consisting of 92 patients 
      fulfilling the inclusion criteria who were admitted to Bangalore Baptist 
      Hospital, Bengaluru, between March 2008 and July 2009 were randomised to receive 
      Unfractionated heparin (UFH) or Low-molecular weight heparin (LMWH). RESULTS: The 
      result based on intention to treat (ITT)analysis with best outcome scenario: in 
      the UFH arm there were 47 (97.9%) patients who had not developed DVT/PE as 
      compared to 42 (95.5%) in the LMWH arm. The difference in proportion of patients 
      who had not developed DVT/PE between UFH and LMWH was 2.4% (-5.0, 9.8). The 
      results based on per protocol analysis: In the UFH arm there were 44 (97.8%) 
      patients who had not developed DVT/PE as compared to 39 (95.1%) in the LMWH arm. 
      The difference in proportion of patients who had not developed DVT/PE between the 
      UFH and LMWH arm was 2.7% (-5.2, 10.5). Patients on UFH had higher major bleeding 
      complications 4 (8.9%) as compared to 0 in LMWH arm. But with respect to other 
      complications like thrombocytopenia (HIT) and mild or minimal bleeding both arms 
      were comparable. CONCLUSION: This study has demonstrated that low dose UFH is as 
      effective as LMWH as a prophylactic agent for venous thromboembolism in medically 
      ill patients and economical also.
FAU - Ishi, Sandeep V
AU  - Ishi SV
FAU - Lakshmi, M
AU  - Lakshmi M
FAU - Kakde, Shailesh T
AU  - Kakde ST
FAU - Sabnis, Kirti C
AU  - Sabnis KC
FAU - Jagannati, Manjeera
AU  - Jagannati M
FAU - Girish, T S
AU  - Girish TS
FAU - Jeyaseelan, L
AU  - Jeyaseelan L
FAU - Cherian, A M
AU  - Cherian AM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - J Assoc Physicians India
JT  - The Journal of the Association of Physicians of India
JID - 7505585
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Anticoagulants/*administration & dosage/adverse effects
MH  - Double-Blind Method
MH  - Enoxaparin/*administration & dosage/adverse effects
MH  - Female
MH  - Heparin/*administration & dosage/adverse effects
MH  - Humans
MH  - Intention to Treat Analysis
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Pulmonary Embolism/*prevention & control
MH  - Venous Thrombosis/*prevention & control
EDAT- 2014/06/28 06:00
MHDA- 2014/07/30 06:00
CRDT- 2014/06/28 06:00
PHST- 2014/06/28 06:00 [entrez]
PHST- 2014/06/28 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
PST - ppublish
SO  - J Assoc Physicians India. 2013 Dec;61(12):882-6.