PMID- 24968785
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20140627
IS  - 1875-7855 (Electronic)
IS  - 0079-6123 (Linking)
VI  - 211
DP  - 2014
TI  - Effects of prenatal exposure to cocaine on brain structure and function.
PG  - 277-89
LID - B978-0-444-63425-2.00012-X [pii]
LID - 10.1016/B978-0-444-63425-2.00012-X [doi]
AB  - Drug abuse during pregnancy affects the mother and has adverse effects on the 
      unborn child. This chapter highlights our recent findings at the neuroanatomical, 
      molecular, and behavioral levels in a prenatal cocaine exposure mouse model. In 
      the embryonic brains of prenatally cocaine-exposed mice, we observed a delay in 
      the tangential migration of GABA neurons to the cerebral cortex as a result of a 
      significant but transient decrease in the expression of the neurotrophin 
      brain-derived neurotrophic factor (BDNF). These developmental changes lead to 
      lasting deficits in the numerical density of GABA neurons in the mature medial 
      prefrontal cortex (mPFC). In adult prenatally cocaine-exposed mice, we observed a 
      behavioral deficit in the recall of an extinguished cue-conditioned fear, which 
      was rescued by administration of exogenous recombinant BDNF protein directly into 
      the infralimbic cortex of the mPFC, which may result from altered activity-driven 
      transcriptional regulation of BDNF.
CI  - (c) 2014 Elsevier B.V. All rights reserved.
FAU - McCarthy, Deirdre M
AU  - McCarthy DM
AD  - Center for Brain Repair, Department of Biomedical Sciences, Florida State 
      University College of Medicine, Tallahassee, FL, USA.
FAU - Kabir, Zeeba D
AU  - Kabir ZD
AD  - Division of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medical 
      College, New York, NY, USA; Brain and Mind Institute, Weill Cornell Medical 
      College, New York, NY, USA.
FAU - Bhide, Pradeep G
AU  - Bhide PG
AD  - Center for Brain Repair, Department of Biomedical Sciences, Florida State 
      University College of Medicine, Tallahassee, FL, USA.
FAU - Kosofsky, Barry E
AU  - Kosofsky BE
AD  - Division of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medical 
      College, New York, NY, USA; Brain and Mind Institute, Weill Cornell Medical 
      College, New York, NY, USA. Electronic address: bar2009@med.cornell.edu.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Prog Brain Res
JT  - Progress in brain research
JID - 0376441
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects
MH  - Cocaine/*toxicity
MH  - Disease Models, Animal
MH  - Dopamine Uptake Inhibitors/*toxicity
MH  - Female
MH  - Mice
MH  - Neurogenesis/*drug effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
OTO - NOTNLM
OT  - BDNF
OT  - GABA
OT  - cocaine
OT  - dopamine
OT  - fear extinction
EDAT- 2014/06/28 06:00
MHDA- 2015/04/07 06:00
CRDT- 2014/06/28 06:00
PHST- 2014/06/28 06:00 [entrez]
PHST- 2014/06/28 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - B978-0-444-63425-2.00012-X [pii]
AID - 10.1016/B978-0-444-63425-2.00012-X [doi]
PST - ppublish
SO  - Prog Brain Res. 2014;211:277-89. doi: 10.1016/B978-0-444-63425-2.00012-X.