PMID- 24970379
OWN - NLM
STAT- MEDLINE
DCOM- 20150819
LR  - 20191210
IS  - 1520-6882 (Electronic)
IS  - 0003-2700 (Linking)
VI  - 86
IP  - 15
DP  - 2014 Aug 5
TI  - Paper spray and extraction spray mass spectrometry for the direct and 
      simultaneous quantification of eight drugs of abuse in whole blood.
PG  - 7712-8
LID - 10.1021/ac5016408 [doi]
AB  - Determination of eight drugs of abuse in blood has been performed using paper 
      spray or extraction spray mass spectrometry in under 2 min with minimal sample 
      preparation. A method has been optimized for quantification of amphetamine, 
      methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 
      3,4-methylenedioxy-N-methylamphetamine (MDMA), 
      3,4-methylenedioxy-N-ethylamphetamine (MDEA), morphine, cocaine, and 
      Delta9-tetrahydrocannabinol (THC) from a single blood spot. Sample to sample 
      variations of 1-5% relative standard deviation were achieved using stable 
      isotope-labeled internal standards and tandem mass spectrometry. Limits of 
      detection for all drugs were below typical physiological and toxicological 
      levels. Paper spray and extraction spray each used less than 10 muL of whole 
      blood. These methods exhibit the potential for performing rapid and 
      high-throughput assays for selective on-site multicompound quantitative screening 
      of illicit drugs.
FAU - Espy, Ryan D
AU  - Espy RD
AD  - Department of Chemistry and Center for Analytical Instrumentation, Purdue 
      University , West Lafayette, Indiana 47907, United States.
FAU - Teunissen, Sebastiaan Frans
AU  - Teunissen SF
FAU - Manicke, Nicholas E
AU  - Manicke NE
FAU - Ren, Yue
AU  - Ren Y
FAU - Ouyang, Zheng
AU  - Ouyang Z
FAU - van Asten, Arian
AU  - van Asten A
FAU - Cooks, R Graham
AU  - Cooks RG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140709
PL  - United States
TA  - Anal Chem
JT  - Analytical chemistry
JID - 0370536
RN  - 0 (Illicit Drugs)
SB  - IM
MH  - Humans
MH  - Illicit Drugs/*blood
MH  - Limit of Detection
MH  - Mass Spectrometry/*methods
MH  - *Paper
EDAT- 2014/06/28 06:00
MHDA- 2015/08/20 06:00
CRDT- 2014/06/28 06:00
PHST- 2014/06/28 06:00 [entrez]
PHST- 2014/06/28 06:00 [pubmed]
PHST- 2015/08/20 06:00 [medline]
AID - 10.1021/ac5016408 [doi]
PST - ppublish
SO  - Anal Chem. 2014 Aug 5;86(15):7712-8. doi: 10.1021/ac5016408. Epub 2014 Jul 9.