PMID- 24970723
OWN - NLM
STAT- MEDLINE
DCOM- 20150629
LR  - 20220408
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 15
IP  - 11
DP  - 2014 Nov
TI  - Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: 
      a multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study 
      assessing potential mechanisms.
PG  - 1263-9
LID - 10.1093/ehjci/jeu121 [doi]
AB  - AIMS: To assess the cardiac, vascular, anthropometric, and biochemical 
      determinants of subclinical diastolic dysfunction in younger adults with Type 2 
      diabetes mellitus (T2DM) using multiparametric contrast-enhanced cardiovascular 
      magnetic resonance (CMR) imaging. METHODS AND RESULTS: Twenty adults <40 years 
      with T2DM [mean age 31.8(6.6) years, T2DM duration 4.7(4.0) years] and 20 age and 
      sex-matched controls [10 obese non-diabetic controls and 10 lean controls (LC)] 
      were studied. Cardiac volumes and function, circumferential strain and peak early 
      diastolic strain rate (PEDSR), myocardial perfusion reserve, aortic stiffness 
      (distensibility, pulse-wave velocity), focal fibrosis on late gadolinium 
      enhancement, and pre- and post-contrast T1 mapping for contrast agent partition 
      coefficient (subset, n = 26) were determined by CMR. In the T2DM cohort, mean 
      aortic distensibility correlated with PEDSR (r = 0.564, P = 0.023) and diabetes 
      duration correlated inversely with PEDSR (r = -0.534, P = 0.015) on univariate 
      analysis. There was a close association between PEDSR and peak systolic strain (r 
      = -0.580, P = 0.007). CONCLUSION: In young adults with T2DM, diabetes duration 
      and aortic distensibility were associated with diastolic dysfunction. 
      Interventional studies are required to assess whether cardiac dysfunction can be 
      reversed in this phenotype of patients.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author 2014. For permissions please email: journals.permissions@oup.com.
FAU - Khan, Jamal Nasir
AU  - Khan JN
AD  - Department of Cardiovascular Sciences, University of Leicester, Glenfield 
      Hospital, Groby Road, Leicester LE3 9QP, UK The NIHR Leicester Cardiovascular 
      Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
FAU - Wilmot, Emma Gwyn
AU  - Wilmot EG
AD  - Department of Cardiovascular Sciences, University of Leicester, Glenfield 
      Hospital, Groby Road, Leicester LE3 9QP, UK The NIHR Leicester Cardiovascular 
      Biomedical Research Unit, Glenfield Hospital, Leicester, UK Diabetes Research 
      Unit, University of Leicester, Leicester Diabetes Centre, Leicester General 
      Hospital, Leicester, UK The NIHR Leicester Loughborough Diet, Lifestyle and 
      Physical Activity Biomedical Research Unit, Leicester Diabetes Centre, Leicester 
      General Hospital, Leicester, UK.
FAU - Leggate, Melanie
AU  - Leggate M
AD  - The NIHR Leicester Loughborough Diet, Lifestyle and Physical Activity Biomedical 
      Research Unit, Leicester Diabetes Centre, Leicester General Hospital, Leicester, 
      UK School of Sport, Exercise and Health Sciences, Loughborough University, 
      Leicestershire, Leicester, UK.
FAU - Singh, Anvesha
AU  - Singh A
AD  - Department of Cardiovascular Sciences, University of Leicester, Glenfield 
      Hospital, Groby Road, Leicester LE3 9QP, UK The NIHR Leicester Cardiovascular 
      Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
FAU - Yates, Thomas
AU  - Yates T
AD  - Diabetes Research Unit, University of Leicester, Leicester Diabetes Centre, 
      Leicester General Hospital, Leicester, UK The NIHR Leicester Loughborough Diet, 
      Lifestyle and Physical Activity Biomedical Research Unit, Leicester Diabetes 
      Centre, Leicester General Hospital, Leicester, UK.
FAU - Nimmo, Myra
AU  - Nimmo M
AD  - The NIHR Leicester Loughborough Diet, Lifestyle and Physical Activity Biomedical 
      Research Unit, Leicester Diabetes Centre, Leicester General Hospital, Leicester, 
      UK School of Sport, Exercise and Health Sciences, Loughborough University, 
      Leicestershire, Leicester, UK.
FAU - Khunti, Kamlesh
AU  - Khunti K
AD  - Diabetes Research Unit, University of Leicester, Leicester Diabetes Centre, 
      Leicester General Hospital, Leicester, UK The NIHR Leicester Loughborough Diet, 
      Lifestyle and Physical Activity Biomedical Research Unit, Leicester Diabetes 
      Centre, Leicester General Hospital, Leicester, UK.
FAU - Horsfield, Mark A
AU  - Horsfield MA
AD  - Department of Cardiovascular Sciences, University of Leicester, Glenfield 
      Hospital, Groby Road, Leicester LE3 9QP, UK The NIHR Leicester Cardiovascular 
      Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
FAU - Biglands, John
AU  - Biglands J
AD  - Cardiovascular Research Department, Leeds General Infirmary, Leeds, West 
      Yorkshire, UK.
FAU - Clarysse, Patrick
AU  - Clarysse P
AD  - CREATIS, Insa de Lyon, Lyon, France.
FAU - Croisille, Pierre
AU  - Croisille P
AD  - CREATIS, Insa de Lyon, Lyon, France.
FAU - Davies, Melanie
AU  - Davies M
AD  - Department of Cardiovascular Sciences, University of Leicester, Glenfield 
      Hospital, Groby Road, Leicester LE3 9QP, UK The NIHR Leicester Cardiovascular 
      Biomedical Research Unit, Glenfield Hospital, Leicester, UK Diabetes Research 
      Unit, University of Leicester, Leicester Diabetes Centre, Leicester General 
      Hospital, Leicester, UK The NIHR Leicester Loughborough Diet, Lifestyle and 
      Physical Activity Biomedical Research Unit, Leicester Diabetes Centre, Leicester 
      General Hospital, Leicester, UK.
FAU - McCann, Gerry Patrick
AU  - McCann GP
AD  - Department of Cardiovascular Sciences, University of Leicester, Glenfield 
      Hospital, Groby Road, Leicester LE3 9QP, UK The NIHR Leicester Cardiovascular 
      Biomedical Research Unit, Glenfield Hospital, Leicester, UK 
      gerry.mccann@uhl-tr.nhs.uk.
LA  - eng
GR  - PDF-2011-04-051/DH_/Department of Health/United Kingdom
GR  - RTF/01/014/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140626
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
RN  - 0 (Biomarkers)
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adult
MH  - Anthropometry
MH  - Biomarkers/blood
MH  - Cardiac-Gated Imaging Techniques
MH  - Case-Control Studies
MH  - Contrast Media
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diastole
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Heart Failure, Diastolic/*diagnosis/*etiology/physiopathology
MH  - Heart Function Tests
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Pilot Projects
MH  - Risk Factors
OTO - NOTNLM
OT  - Aortic distensibility
OT  - Cardiac magnetic resonance imaging
OT  - Diabetes mellitus
OT  - Diabetic cardiomyopathies
OT  - Diabetic diastolic heart failure
OT  - Diastolic dysfunction diabetes mellitus
EDAT- 2014/06/28 06:00
MHDA- 2015/06/30 06:00
CRDT- 2014/06/28 06:00
PHST- 2014/06/28 06:00 [entrez]
PHST- 2014/06/28 06:00 [pubmed]
PHST- 2015/06/30 06:00 [medline]
AID - jeu121 [pii]
AID - 10.1093/ehjci/jeu121 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2014 Nov;15(11):1263-9. doi: 
      10.1093/ehjci/jeu121. Epub 2014 Jun 26.