PMID- 24971143
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140627
LR  - 20220318
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2014
DP  - 2014
TI  - Traditional formula, modern application: chinese medicine formula sini tang 
      improves early ventricular remodeling and cardiac function after myocardial 
      infarction in rats.
PG  - 141938
LID - 10.1155/2014/141938 [doi]
LID - 141938
AB  - SINI TANG (SNT) IS A TRADITIONAL CHINESE HERBAL FORMULA CONSISTING OF FOUR 
      DIFFERENT HERBS: the root of Aconitum carmichaelii, the bark of Cinnamomum 
      cassia, the rhizome of Zingiber officinale, and the root of Glycyrrhiza 
      uralensis. This study aims to evaluate the improvement of early ventricular 
      remodeling and cardiac function in myocardial infarction (MI) rats by SNT. A MI 
      model was established by ligation of the left anterior descending coronary 
      artery. Following treatment for 4 weeks, ultrasonic echocardiography was 
      performed. Myocardial histopathological changes were observed using haematoxylin 
      and eosin staining. Collagens (type I and type III), transforming growth factor- 
      beta 1 (TGF- beta 1), and Toll-like receptors (TLR-2 and TLR-4) were measured in 
      plasma, serum, and myocardial tissue. SNT treatment decreased the infarct size, 
      the left ventricular cavity area/heart cavity area ratio, and the left ventricle 
      dimension at end systole and increased the left ventricular ejection fraction. 
      SNT reduced the levels of TLR-2 and TLR-4 in myocardial tissue significantly and 
      decreased the collagens content in serum and in myocardial tissue. SNT could 
      partially reduce the level of TGF- beta 1 in serum and in myocardial tissue. Our 
      data suggest that the Chinese medicine formula SNT has the potential to improve 
      early ventricular remodeling and cardiac function after MI.
FAU - Liu, Jiangang
AU  - Liu J
AD  - Center of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 
      No. 1 Xiyuan Caochang, Haidian District, Beijing 100091, China.
FAU - Peter, Karoline
AU  - Peter K
AD  - Molecular Research in Traditional Chinese Medicine Group, Department of 
      Pathophysiology and Allergy Research, Vienna General Hospital, Medical University 
      of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
FAU - Shi, Dazhuo
AU  - Shi D
AD  - Center of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 
      No. 1 Xiyuan Caochang, Haidian District, Beijing 100091, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Center of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 
      No. 1 Xiyuan Caochang, Haidian District, Beijing 100091, China.
FAU - Dong, Guoju
AU  - Dong G
AD  - Center of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 
      No. 1 Xiyuan Caochang, Haidian District, Beijing 100091, China.
FAU - Zhang, Dawu
AU  - Zhang D
AD  - Center of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, 
      No. 1 Xiyuan Caochang, Haidian District, Beijing 100091, China.
FAU - Breiteneder, Heimo
AU  - Breiteneder H
AD  - Molecular Research in Traditional Chinese Medicine Group, Department of 
      Pathophysiology and Allergy Research, Vienna General Hospital, Medical University 
      of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
FAU - Jakowitsch, Johannes
AU  - Jakowitsch J
AUID- ORCID: 0000-0002-6207-8968
AD  - Clinical Division of Cardiology, Department of Internal Medicine II, Vienna 
      General Hospital, Medical University of Vienna, Waehringer Guertel 18-20, 1090 
      Vienna, Austria.
FAU - Ma, Yan
AU  - Ma Y
AD  - Molecular Research in Traditional Chinese Medicine Group, Department of 
      Pathophysiology and Allergy Research, Vienna General Hospital, Medical University 
      of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
LA  - eng
PT  - Journal Article
DEP - 20140525
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC4058176
EDAT- 2014/06/28 06:00
MHDA- 2014/06/28 06:01
PMCR- 2014/05/25
CRDT- 2014/06/28 06:00
PHST- 2014/02/10 00:00 [received]
PHST- 2014/04/26 00:00 [accepted]
PHST- 2014/06/28 06:00 [entrez]
PHST- 2014/06/28 06:00 [pubmed]
PHST- 2014/06/28 06:01 [medline]
PHST- 2014/05/25 00:00 [pmc-release]
AID - 10.1155/2014/141938 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2014;2014:141938. doi: 10.1155/2014/141938. 
      Epub 2014 May 25.