PMID- 24972301
OWN - NLM
STAT- MEDLINE
DCOM- 20151015
LR  - 20161125
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 275
DP  - 2014 Sep 5
TI  - Genipin is active via modulating monoaminergic transmission and levels of 
      brain-derived neurotrophic factor (BDNF) in rat model of depression.
PG  - 365-73
LID - S0306-4522(14)00517-X [pii]
LID - 10.1016/j.neuroscience.2014.06.032 [doi]
AB  - Genipin, an important bioactive component from Gardenia jasminoides Eills, was 
      demonstrated to possess antidepressant-like effects in a previous study. However, 
      the molecular mechanism of antidepressant-like effects on genipin was not clear. 
      The present study aimed to investigate the possible mechanism of 
      antidepressant-like effects on genipin with a chronic unpredictable mild stress 
      (CUMS)-induced depression model in rats. In CUMS-induced depressive rats, 
      bodyweight and 1% sucrose consumption decreased significantly compared with the 
      normal control group. Furthermore, these changes could be significantly reversed 
      by genipin application. The levels of 5-hydroxytryptamine (5-HT), norepinephrine 
      (NE) in the hippocampus decreased and the level of 5-hydroxyindole acetic acid 
      (5-HIAA) increased in the CUMS-induced depressive rats. However, pre-treatments 
      with genipin significantly increased the levels of 5-HT, NE and decreased the 
      level of 5-HIAA in the hippocampus. The concentration of cAMP in the hippocampus 
      was increased by genipin compared to the CUMS-exposed model group. The mRNA 
      expressions of 5-hydroxytryptamine 1A receptor (5-HT1AR), cAMP response element 
      binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in rats were 
      decreased exposed to CUMS, which were reversed by genipin-treated rats exposed to 
      CUMS. Compared to the CUMS-exposed model group, the mRNA expression of 
      5-hydroxytryptamine 2A receptor (5-HT(2A)R) was decreased significantly by 
      genipin-treated rats. The mRNA and protein expression of CREB, BDNF were 
      increased in genipin-treated rats compared to the CUMS-exposed model group. 
      Moreover, the levels of corticosterone in serum were decreased by genipin-treated 
      compared to the CUMS-exposed model group. These results suggest that the possible 
      mechanism of antidepressant-like effects on genipin, at least in one part, 
      resulted from monoaminergic neurotransmitter system and the potential 
      dysfunctional regulation of the post-receptor signaling pathway, which 
      particularly affected the 5-HT(1A)R, 5-HT(2A)R and BDNF levels in the 
      hippocampus.
CI  - Copyright (c) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Wang, Q-S
AU  - Wang QS
AD  - Tianjin State Key Laboratory of Modern Chinese Medicine, Research Center of 
      Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 
      Tianjin 300193, PR China; Institute of Medical Equipment, Academy of Military 
      Medical Sciences, Tianjin 300161, PR China.
FAU - Tian, J-S
AU  - Tian JS
AD  - Tianjin State Key Laboratory of Modern Chinese Medicine, Research Center of 
      Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 
      Tianjin 300193, PR China; Modern Research Center for Traditional Chinese Medicine 
      of Shanxi University, Taiyuan 030006, PR China.
FAU - Cui, Y-L
AU  - Cui YL
AD  - Tianjin State Key Laboratory of Modern Chinese Medicine, Research Center of 
      Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 
      Tianjin 300193, PR China. Electronic address: cuiyl@tju.edu.cn.
FAU - Gao, S
AU  - Gao S
AD  - Tianjin State Key Laboratory of Modern Chinese Medicine, Research Center of 
      Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 
      Tianjin 300193, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140624
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Iridoids)
RN  - 0 (Receptors, Serotonin)
RN  - 333DO1RDJY (Serotonin)
RN  - A3V2NE52YG (genipin)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Depression/*metabolism/pathology
MH  - Disease Models, Animal
MH  - Hippocampus/drug effects/metabolism
MH  - Iridoids/*pharmacology
MH  - Male
MH  - Phytotherapy/methods
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, Serotonin/biosynthesis/drug effects
MH  - Serotonin/metabolism
MH  - Synaptic Transmission/*drug effects
OTO - NOTNLM
OT  - antidepressant
OT  - brain-derived neurotrophic factor
OT  - chronic unpredictable mild stress
OT  - genipin
OT  - serotonin
EDAT- 2014/06/28 06:00
MHDA- 2015/10/16 06:00
CRDT- 2014/06/28 06:00
PHST- 2014/03/20 00:00 [received]
PHST- 2014/05/30 00:00 [revised]
PHST- 2014/06/17 00:00 [accepted]
PHST- 2014/06/28 06:00 [entrez]
PHST- 2014/06/28 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - S0306-4522(14)00517-X [pii]
AID - 10.1016/j.neuroscience.2014.06.032 [doi]
PST - ppublish
SO  - Neuroscience. 2014 Sep 5;275:365-73. doi: 10.1016/j.neuroscience.2014.06.032. 
      Epub 2014 Jun 24.