PMID- 24972302
OWN - NLM
STAT- MEDLINE
DCOM- 20151015
LR  - 20151209
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 275
DP  - 2014 Sep 5
TI  - Epigenetic and epistatic interactions between serotonin transporter and 
      brain-derived neurotrophic factor genetic polymorphism: insights in depression.
PG  - 455-68
LID - S0306-4522(14)00521-1 [pii]
LID - 10.1016/j.neuroscience.2014.06.036 [doi]
AB  - Epidemiological studies have shown significant results in the interaction between 
      the functions of brain-derived neurotrophic factor (BDNF) and 5-HT in mood 
      disorders, such as major depressive disorder (MDD). The latest research has 
      provided convincing evidence that gene transcription of these molecules is a 
      target for epigenetic changes, triggered by stressful stimuli that starts in 
      early childhood and continues throughout life, which are subsequently translated 
      into structural and functional phenotypes culminating in depressive disorders. 
      The short variants of 5-HTTLPR and BDNF-Met are seen as forms which are 
      predisposed to epigenetic aberrations, which leads individuals to a 
      susceptibility to environmental adversities, especially when subjected to stress 
      in early life. Moreover, the polymorphic variants also feature epistatic 
      interactions in directing the functional mechanisms elicited by stress and 
      underlying the onset of depressive disorders. Also emphasized are works which 
      show some mediators between stress and epigenetic changes of the 5-HTT and BDNF 
      genes, such as the hypothalamic-pituitary-adrenal (HPA) axis and the cAMP 
      response element-binding protein (CREB), which is a cellular transcription 
      factor. Both the HPA axis and CREB are also involved in epistatic interactions 
      between polymorphic variants of 5-HTTLPR and Val66Met. This review highlights 
      some research studying changes in the epigenetic patterns intrinsic to genes of 
      5-HTT and BDNF, which are related to lifelong environmental adversities, which in 
      turn increases the risks of developing MDD.
CI  - Copyright (c) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Ignacio, Z M
AU  - Ignacio ZM
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil; Laboratorio de Fisiologia, Farmacologia, Patologia e 
      Psicopatologia, Campus Chapeco, Universidade Federal da Fronteira Sul - UFFS, 
      Chapeco, SC, Brazil.
FAU - Reus, G Z
AU  - Reus GZ
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil; Center for Experimental Models in Psychiatry, Department of 
      Psychiatry and Behavioral Sciences, Medical School, The University of Texas 
      Health Science Center at Houston, Houston, TX, USA. Electronic address: 
      gislainezilli@hotmail.com.
FAU - Abelaira, H M
AU  - Abelaira HM
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil.
FAU - Quevedo, J
AU  - Quevedo J
AD  - Laboratorio de Neurociencias, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      Criciuma, SC, Brazil; Center for Experimental Models in Psychiatry, Department of 
      Psychiatry and Behavioral Sciences, Medical School, The University of Texas 
      Health Science Center at Houston, Houston, TX, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140624
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*genetics
MH  - Depression/*genetics
MH  - Epigenesis, Genetic/*genetics
MH  - Epistasis, Genetic/*genetics
MH  - Gene Expression Regulation
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Serotonin Plasma Membrane Transport Proteins/biosynthesis/*genetics
OTO - NOTNLM
OT  - BDNF
OT  - depression
OT  - epigenetic
OT  - lifelong stress
OT  - polymorphism
OT  - serotonin transporter
EDAT- 2014/06/28 06:00
MHDA- 2015/10/16 06:00
CRDT- 2014/06/28 06:00
PHST- 2014/05/21 00:00 [received]
PHST- 2014/06/13 00:00 [revised]
PHST- 2014/06/17 00:00 [accepted]
PHST- 2014/06/28 06:00 [entrez]
PHST- 2014/06/28 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - S0306-4522(14)00521-1 [pii]
AID - 10.1016/j.neuroscience.2014.06.036 [doi]
PST - ppublish
SO  - Neuroscience. 2014 Sep 5;275:455-68. doi: 10.1016/j.neuroscience.2014.06.036. 
      Epub 2014 Jun 24.