PMID- 24972609
OWN - NLM
STAT- MEDLINE
DCOM- 20150327
LR  - 20211021
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 9
DP  - 2014 Jun 27
TI  - Significant association between TAP2 polymorphisms and rheumatoid arthritis: a 
      meta-analysis.
PG  - 129
LID - 10.1186/1746-1596-9-129 [doi]
AB  - BACKGROUND: Rheumatoid arthritis (RA) is a severe chronic immune mediated 
      inflammatory disease that has been shown to be associated with human leukocyte 
      antigen (HLA) loci. The transporter associated with antigen processing 2 (TAP2) 
      has been identified to play an important role in the HLA-associated diseases and 
      immune response. The goal of our meta-analysis was to summarize the contribution 
      of TAP2 polymorphisms to the risk of RA. METHODS: Meta-analyses were performed 
      between RA and 3 TAP2 coding polymorphisms that comprised TAP2-379Ile > Val 
      (rs1800454), TAP2-565Ala > Thr (rs2228396) and TAP2-665Thr > Ala (rs241447). The 
      meta-analyses were involved with 9 studies (24 individual studies) among 973 
      cases and 965 controls. RESULTS: Meta-analyses showed that TAP2-379Ile allele was 
      significantly associated with an increased risk of RA (p = 0.0002, odds ratio 
      (OR) = 1.44, 95% confidence interval (CI) = 1.18-1.74). This association was 
      further shown only in the dominant model (p = 0.006, OR = 1.59, 95% 
      CI = 1.14-2.22). Subgroup analyses by ethnicity revealed that the association of 
      TAP2-379Ile was significant in Asians (p = 0.03, OR = 1.38, 95% CI = 1.04-1.83). 
      In addition, another significant association of TAP2-565Thr allele with RA was 
      observed in Europeans (p = 0.002, OR = 1.62, 95% CI = 1.20-2.20). CONCLUSIONS: 
      Our meta-analyses suggested that TAP2-379Ile allele was significantly associated 
      with a 59% increased risk in the dominant effect model. Subgroup analyses by 
      ethnicity showed that TAP2-379-Ile increased the risk of RA by 38% in Asians and 
      TAP2-565Thr increased the risk of RA by 38% in Europeans. VIRTUAL SLIDES: The 
      virtual slide(s) for this article can be found here: 
      http://www.diagnosticpathology.diagnomx.eu/vs/2097080313124700.
FAU - Dai, Dongjun
AU  - Dai D
FAU - Chen, Yong
AU  - Chen Y
FAU - Ru, Ping
AU  - Ru P
FAU - Zhou, Xingyu
AU  - Zhou X
FAU - Tao, Jianmin
AU  - Tao J
FAU - Ye, Huadan
AU  - Ye H
FAU - Hong, Qingxiao
AU  - Hong Q
FAU - Tang, Linlin
AU  - Tang L
FAU - Pan, Guanghui
AU  - Pan G
FAU - Lin, Danfeng
AU  - Lin D
FAU - Gong, Qiongyao
AU  - Gong Q
FAU - Lv, Yuelong
AU  - Lv Y
FAU - Xu, Leiting
AU  - Xu L
FAU - Duan, Shiwei
AU  - Duan S
AD  - Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo 
      University, Ningbo, Zhejiang 315211, China. duanshiwei@nbu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20140627
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 3)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 145892-13-3 (TAP2 protein, human)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 3
MH  - ATP-Binding Cassette Transporters/*genetics
MH  - Arthritis, Rheumatoid/*genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
PMC - PMC4090395
EDAT- 2014/06/29 06:00
MHDA- 2015/04/02 06:00
PMCR- 2014/06/27
CRDT- 2014/06/29 06:00
PHST- 2014/03/21 00:00 [received]
PHST- 2014/06/23 00:00 [accepted]
PHST- 2014/06/29 06:00 [entrez]
PHST- 2014/06/29 06:00 [pubmed]
PHST- 2015/04/02 06:00 [medline]
PHST- 2014/06/27 00:00 [pmc-release]
AID - 1746-1596-9-129 [pii]
AID - 10.1186/1746-1596-9-129 [doi]
PST - epublish
SO  - Diagn Pathol. 2014 Jun 27;9:129. doi: 10.1186/1746-1596-9-129.