PMID- 24972865
OWN - NLM
STAT- MEDLINE
DCOM- 20151123
LR  - 20141202
IS  - 1878-4119 (Electronic)
IS  - 1010-5182 (Linking)
VI  - 42
IP  - 7
DP  - 2014 Oct
TI  - Bone tissue response to an oily calcium hydroxide suspension in tibial defects. 
      An experimental pilot study in minipigs.
PG  - 1171-7
LID - S1010-5182(14)00064-X [pii]
LID - 10.1016/j.jcms.2014.02.004 [doi]
AB  - OBJECTIVES: The present study was conducted to evaluate the bone tissue response 
      after the application of an oily calcium hydroxide suspension (OCHS) into defects 
      created in the tibial bone of minipigs. MATERIALS AND METHODS: Standardized 
      defects (2 ccm) were created into the tibia of 4 Goettinger minipigs. Defects in 
      the test group (n = 4) were filled with OCHS (Osteora, DFS-Diamon, Riedenburg, 
      Germany). Defects in the control group (n = 4) were filled with venous blood. 
      Animals were sacrificed after healing periods of 4 and 8 weeks. Tibias were 
      dissected, soft tissues removed and processed for histological analysis. Digital 
      images (x200) were evaluated using the software CellD (Soft Imaging System, 
      Munster, Germany). The following histomorphometrical landmarks were identified: 
      defect size, mineralized tissue, non-mineralized tissue and residual OCHS. 
      RESULTS: Healing was uneventful in all four animals. In the test group, new bone 
      formation was observed in the vicinity of the defect margins whereas the centre 
      of the defect was dominated by non-mineralized tissue. Mean percentages of 
      mineralized tissue after 4 weeks were 23.01% in the test group vs. 43.45% in the 
      control group. The mean value for residual OCHS was 7,11% at 4 weeks. After 8 
      weeks mean percentages of mineralized tissue were 28.15% in the test group vs. 
      44.39% in the control group as well as 7.05% for residual OCHS. CONCLUSION: 
      Within the limits of the present pilot study it can be concluded that OCHS did 
      not have a beneficial effect on new bone formation. To prove an osteoinductive 
      potential of OCHS further studies based on a higher number of samples are needed.
CI  - Copyright (c) 2014 European Association for Cranio-Maxillo-Facial Surgery. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Mihatovic, I
AU  - Mihatovic I
AD  - Department of Oral Surgery, Heinrich Heine University, Westdeutsche Kieferklinik, 
      Moorenstr. 5, D-40225 Dusseldorf, Germany. Electronic address: 
      ilja.mihatovic@med.uni-duesseldorf.de.
FAU - Payer, M
AU  - Payer M
AD  - Department of Oral Surgery and Radiology, School of Dentistry, Medical University 
      of Graz, Austria.
FAU - Bertrams, M
AU  - Bertrams M
AD  - Department of Oral Surgery, Heinrich Heine University, Westdeutsche Kieferklinik, 
      Moorenstr. 5, D-40225 Dusseldorf, Germany.
FAU - Vasiliu, D
AU  - Vasiliu D
AD  - Department of Oral Surgery and Radiology, School of Dentistry, Medical University 
      of Graz, Austria.
FAU - Schwarz, F
AU  - Schwarz F
AD  - Department of Oral Surgery, Heinrich Heine University, Westdeutsche Kieferklinik, 
      Moorenstr. 5, D-40225 Dusseldorf, Germany.
FAU - Becker, J
AU  - Becker J
AD  - Department of Oral Surgery, Heinrich Heine University, Westdeutsche Kieferklinik, 
      Moorenstr. 5, D-40225 Dusseldorf, Germany.
FAU - Stratul, S I
AU  - Stratul SI
AD  - Department of Periodontology, Victor Babes University of Medicine, Timisoara, 
      Romania.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140310
PL  - Scotland
TA  - J Craniomaxillofac Surg
JT  - Journal of cranio-maxillo-facial surgery : official publication of the European 
      Association for Cranio-Maxillo-Facial Surgery
JID - 8704309
RN  - 0 (Bone Substitutes)
RN  - PF5DZW74VN (Calcium Hydroxide)
SB  - IM
MH  - Animals
MH  - Blood Coagulation/physiology
MH  - Bone Diseases/pathology/*surgery
MH  - Bone Substitutes/*therapeutic use
MH  - Calcification, Physiologic/drug effects
MH  - Calcium Hydroxide/*therapeutic use
MH  - Disease Models, Animal
MH  - Osteogenesis/drug effects
MH  - Random Allocation
MH  - Swine
MH  - Swine, Miniature
MH  - Tibia/*drug effects/pathology
MH  - Time Factors
MH  - Wound Healing/physiology
OTO - NOTNLM
OT  - Animal study
OT  - Bone graft
OT  - Bone regeneration
OT  - Calcium hydroxide suspension
OT  - Tibial defect
EDAT- 2014/06/29 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/06/29 06:00
PHST- 2013/07/17 00:00 [received]
PHST- 2013/12/09 00:00 [revised]
PHST- 2014/02/10 00:00 [accepted]
PHST- 2014/06/29 06:00 [entrez]
PHST- 2014/06/29 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S1010-5182(14)00064-X [pii]
AID - 10.1016/j.jcms.2014.02.004 [doi]
PST - ppublish
SO  - J Craniomaxillofac Surg. 2014 Oct;42(7):1171-7. doi: 10.1016/j.jcms.2014.02.004. 
      Epub 2014 Mar 10.