PMID- 24974147
OWN - NLM
STAT- MEDLINE
DCOM- 20140924
LR  - 20201209
IS  - 1873-5835 (Electronic)
IS  - 0145-2126 (Linking)
VI  - 38
IP  - 8
DP  - 2014 Aug
TI  - Expression of small glutamine-rich TPR-containing protein A (SGTA) in 
      Non-Hodgkin's Lymphomas promotes tumor proliferation and reverses cell 
      adhesion-mediated drug resistance (CAM-DR).
PG  - 955-63
LID - S0145-2126(14)00154-4 [pii]
LID - 10.1016/j.leukres.2014.05.013 [doi]
AB  - The expression and biologic function of SGTA in Non-Hodgkin's Lymphomas (NHL) was 
      investigated in this study. Clinically, by immunohistochemistry analysis we 
      detected SGTA expression in both reactive lymphoid tissues and NHL tissues. In 
      addition, we also correlated high expression of SGTA with poor prognosis. 
      Functionally, SGTA expression was positively related with cell proliferation and 
      negative related with cell adhesion. Finally, SGTA knockdown induced 
      adhesion-mediated drug resistance. Our finding supports a role of SGTA in NHL 
      cell proliferation, adhesion and drug resistance, and it may pave the way for a 
      novel therapeutic approach for CAM-DR in NHL.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Wang, Yuchan
AU  - Wang Y
AD  - Department of Pathology, Affiliated Cancer Hospital of Nantong University, 
      Nantong 226361, Jiangsu, China.
FAU - Huang, Yuejiao
AU  - Huang Y
AD  - Department of Pathology, Medical College, Nantong University, Nantong 226001, 
      Jiangsu, China.
FAU - Xu, Xiaohong
AU  - Xu X
AD  - Department of Pathology, Affiliated Cancer Hospital of Nantong University, 
      Nantong 226361, Jiangsu, China.
FAU - Tang, Jie
AU  - Tang J
AD  - Department of Pathology, Medical College, Nantong University, Nantong 226001, 
      Jiangsu, China.
FAU - Huang, Xianting
AU  - Huang X
AD  - Department of Pathology, Medical College, Nantong University, Nantong 226001, 
      Jiangsu, China.
FAU - Zhu, Junya
AU  - Zhu J
AD  - Department of Pathology, Medical College, Nantong University, Nantong 226001, 
      Jiangsu, China.
FAU - Liu, Jing
AU  - Liu J
AD  - Department of Pathology, Medical College, Nantong University, Nantong 226001, 
      Jiangsu, China.
FAU - Miao, Xiaobing
AU  - Miao X
AD  - Department of Pathology, Affiliated Cancer Hospital of Nantong University, 
      Nantong 226361, Jiangsu, China.
FAU - Wu, Yaxun
AU  - Wu Y
AD  - Department of Pathology, Affiliated Cancer Hospital of Nantong University, 
      Nantong 226361, Jiangsu, China.
FAU - Yang, Fan
AU  - Yang F
AD  - Department of Pediatrics, Medical College, Nantong University, Nantong 226001, 
      Jiangsu, China.
FAU - Ji, Lili
AU  - Ji L
AD  - Department of Pathology, Medical College, Nantong University, Nantong 226001, 
      Jiangsu, China. Electronic address: liliji79@ntu.edu.cn.
FAU - He, Song
AU  - He S
AD  - Department of Pathology, Affiliated Cancer Hospital of Nantong University, 
      Nantong 226361, Jiangsu, China. Electronic address: hesong2009@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140602
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Carrier Proteins)
RN  - 0 (Molecular Chaperones)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (SGTA protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - Carrier Proteins/genetics/*metabolism
MH  - Cell Adhesion/drug effects/genetics
MH  - *Cell Proliferation/drug effects
MH  - *Drug Resistance, Neoplasm/drug effects/genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - Lymphoma, Non-Hodgkin/*metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Molecular Chaperones
MH  - RNA, Small Interfering/genetics
MH  - Tumor Cells, Cultured
OTO - NOTNLM
OT  - Cell adhesion
OT  - Drug resistance
OT  - Non-Hodgkin's Lymphomas (NHL)
OT  - Proliferation
OT  - SGTA
EDAT- 2014/06/30 06:00
MHDA- 2014/09/25 06:00
CRDT- 2014/06/30 06:00
PHST- 2013/12/29 00:00 [received]
PHST- 2014/05/09 00:00 [revised]
PHST- 2014/05/21 00:00 [accepted]
PHST- 2014/06/30 06:00 [entrez]
PHST- 2014/06/30 06:00 [pubmed]
PHST- 2014/09/25 06:00 [medline]
AID - S0145-2126(14)00154-4 [pii]
AID - 10.1016/j.leukres.2014.05.013 [doi]
PST - ppublish
SO  - Leuk Res. 2014 Aug;38(8):955-63. doi: 10.1016/j.leukres.2014.05.013. Epub 2014 
      Jun 2.