PMID- 24974442
OWN - NLM
STAT- MEDLINE
DCOM- 20140731
LR  - 20140630
IS  - 0305-7518 (Print)
IS  - 0305-7518 (Linking)
VI  - 85
IP  - 1
DP  - 2014 Mar
TI  - Prostatic and testicular parameters in lepromatous patients.
PG  - 48-53
AB  - OBJECTIVES: To evaluate PSA (Prostate-specific antigen) parameters in patients 
      with lepromatous leprosy (LL). DESIGN: In a retrospective study, 23 male patients 
      with LL were evaluated. PSA parameters (serum total PSA (tPSA), free PSA (fPSA), 
      free-to-total PSA ratio (f/tPSA), PSA Density (PSAD)) were assessed. PSA 
      parameters were compared with a control group. RESULTS: The mean tPSA, fPSA, 
      f/tPSA, prostate volume, and PSAD values of the patient group with LL were 1.87 
      +/- 0.81 ng/ml, 0.67 +/- 0.29 ng/ml, 0.36 +/- 0.11, 41.08 +/- 23.65 ml and 0.055 
      +/- 0.037, respectively. The mean tPSA, fPSA, f/tPSA, prostate volume, and PSAD 
      values of the control group were 2.71 +/- 0.91 ng/ml, 0.80 +/- 0.34 ng/ml, 0.30 
      +/- 0.08, 65.0 +/- 28.73 ml and 0.049 +/- 0.028, respectively. The mean tPSA and 
      prostate volume values were found to be significantly lower in the patient group 
      with LL (p = 0.002 and 0.004, respectively). No significant difference was found 
      between two groups in terms of mean fPSA and PSAD values (p = 0.18 and 0.5, 
      respectively). The mean f/tPSA value was found to be significantly higher in the 
      patient group with LL (p = 0.02). Testes in 16 (69%) patients with LL were 
      bilaterally atrophic. CONCLUSIONS: Serum tPSA values and prostate volumes in the 
      patients with LL were significantly reduced and f/tPSA values were significantly 
      increased. Testicular atrophy in the lepromatous cases might be due to 
      leprosy-related orchitis and associated with a reduction in prostatic volume.
FAU - Aglamis, Erdogan
AU  - Aglamis E
FAU - Tasdemir, Cemal
AU  - Tasdemir C
FAU - Yucel, Mehmet Ozgur
AU  - Yucel MO
FAU - Ceylan, Cavit
AU  - Ceylan C
FAU - Erden, Ilker
AU  - Erden I
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lepr Rev
JT  - Leprosy review
JID - 0243711
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Humans
MH  - Leprosy, Lepromatous/blood/*pathology/physiopathology
MH  - Male
MH  - Organ Size
MH  - Prostate/growth & development/*pathology
MH  - Prostate-Specific Antigen/*blood
MH  - Retrospective Studies
MH  - Testis/*pathology
EDAT- 2014/07/01 06:00
MHDA- 2014/08/01 06:00
CRDT- 2014/07/01 06:00
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2014/08/01 06:00 [medline]
PST - ppublish
SO  - Lepr Rev. 2014 Mar;85(1):48-53.