PMID- 24974453
OWN - NLM
STAT- MEDLINE
DCOM- 20140806
LR  - 20201209
IS  - 0387-5911 (Print)
IS  - 0387-5911 (Linking)
VI  - 88
IP  - 3
DP  - 2014 May
TI  - [Bacterial meningitis caused by beta-lactamase-negative, ampicillin-resistant 
      nontypeable Haemophilus influenzae in a 1-year-old girl: a case report].
PG  - 291-6
AB  - We present herein the case report of bacterial meningitis caused by nontypeable 
      Haemophilus influenzae (NTHi) in a 1-year-7-month-old girl with no medically 
      significant history. NTHi from cerebrospinal fluid (CSF) was the beta-lactamase 
      non-producing ampicillin resistant strain (BLNAR). Some beta-lactams were 
      administrated, but fever was prolonged. Finally, rifampicin seemed to be 
      effective. In NTHi, compared with H. influenzae type b (Hib), the prevalence of 
      BLNAR is high. Hence, complicated cases may increase in the near future if the 
      use of the Hib vaccine becomes widespread, and meningitis caused by NTHi 
      increases. It may be necessary to consider combination therapy or use of 
      non-beta-lactams that have a different antimicrobial mechanism from beta-lactams. 
      PCR analysis revealed the possibility that the CSF isolate lacked the P5 protein 
      gene. Though deficiency of P5 fimbriae is known to reduce the affinity of NTHi 
      for the human respiratory epithelium, determining whether P5 deficient NTHi 
      induced meningitis will require further study.
FAU - Abe, Katsuaki
AU  - Abe K
FAU - Hoshino, Tadashi
AU  - Hoshino T
FAU - Imuta, Naoko
AU  - Imuta N
FAU - Nishi, Junichiro
AU  - Nishi J
FAU - Ishiwada, Naruhiko
AU  - Ishiwada N
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Kansenshogaku Zasshi
JT  - Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious 
      Diseases
JID - 0236671
RN  - EC 3.5.2.6 (beta-Lactamases)
SB  - IM
MH  - *Ampicillin Resistance
MH  - Female
MH  - Haemophilus influenzae/drug effects/enzymology/*isolation & purification
MH  - Humans
MH  - Infant
MH  - Meningitis, Haemophilus/*microbiology
MH  - beta-Lactamases/analysis
EDAT- 2014/07/01 06:00
MHDA- 2014/08/07 06:00
CRDT- 2014/07/01 06:00
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2014/08/07 06:00 [medline]
AID - 10.11150/kansenshogakuzasshi.88.291 [doi]
PST - ppublish
SO  - Kansenshogaku Zasshi. 2014 May;88(3):291-6. doi: 
      10.11150/kansenshogakuzasshi.88.291.