PMID- 24974580
OWN - NLM
STAT- MEDLINE
DCOM- 20140820
LR  - 20140630
IS  - 0031-7144 (Print)
IS  - 0031-7144 (Linking)
VI  - 69
IP  - 6
DP  - 2014 Jun
TI  - Statins in nervous system-associated diseases: angels or devils?
PG  - 448-54
AB  - Statins are commonly prescribed lipid-lowering medications that significantly 
      reduce the risk of cardiovascular events. In addition to their ability to lower 
      cholesterol by affecting the rate-limiting step in cholesterol biosynthesis, 
      statins also have anti-inflammatory, immunomodulatory, antioxidant, 
      antiapoptotic, and antiplatelet effects. Because of these pleiotropic abilities, 
      statins may have some beneficial effects on neurologic diseases, including 
      cerebrovascular disease, neurodegenerative disease, multiple sclerosis, and brain 
      tumors. Although statins are a well-tolerated class of drugs, they also have 
      potential adverse effects (AEs). A growing body of evidence indicates that 
      statins may have potential negative effects on nervous system-associated 
      diseases, including myopathies, peripheral neuropathy, intracerebral hemorrhage 
      (ICH), and other diseases of the central nervous system (e.g., cognitive 
      impairment, depression, sleep disorders, nightmare, and headache). Clinicians, 
      especially neurologists, should be aware of the potential risk of neuropathy in 
      patients who take statins.
FAU - Lei, Q
AU  - Lei Q
FAU - Peng, W N
AU  - Peng WN
FAU - You, H
AU  - You H
FAU - Hu, Z P
AU  - Hu ZP
FAU - Lu, W
AU  - Lu W
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Pharmazie
JT  - Die Pharmazie
JID - 9800766
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Animals
MH  - Brain Neoplasms/drug therapy/pathology
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
MH  - Nervous System Diseases/*chemically induced/*drug therapy/epidemiology
MH  - Neurodegenerative Diseases/drug therapy/epidemiology
EDAT- 2014/07/01 06:00
MHDA- 2014/08/21 06:00
CRDT- 2014/07/01 06:00
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2014/08/21 06:00 [medline]
PST - ppublish
SO  - Pharmazie. 2014 Jun;69(6):448-54.