PMID- 24976281
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211021
IS  - 1998-4049 (Electronic)
IS  - 1319-3767 (Print)
IS  - 1319-3767 (Linking)
VI  - 20
IP  - 3
DP  - 2014 May-Jun
TI  - Effect of HLA on hepatitis C virus clearance and persistence in anti-HCV-positive 
      end-stage renal disease patients.
PG  - 175-81
LID - 10.4103/1319-3767.133007 [doi]
AB  - BACKGROUND/AIMS: The efficacy of immune response against hepatitis C virus (HCV) 
      is determined by human leukocyte antigen (HLA) molecules of the host which 
      present HCV antigens to CD4 + and CD8 + T lymphocytes. In this study, we aimed to 
      investigate the possible relationship between the frequencies of certain HLA 
      class I-II alleles and the natural history of HCV in patients with end-stage 
      renal disease (ESRD). SETTINGS AND DESIGN: This is a retrospective cohort study 
      conducted in a university hospital. PATIENTS AND METHODS: The present study 
      comprised 189 ESRD patients (candidates for renal transplantation) who had 
      positive anti-HCV antibody test. The results concerning HCV and HLA status were 
      gathered from patients' files. The viral persistence was compared between the 
      groups that were determined by HLA sub-typing. STATISTICAL ANALYSIS: Statistical 
      evaluation was performed using Mann-Whitney U-test, Chi-square test, and Fisher's 
      exact test. Level of error was set at 0.05 for all statistical evaluations, and P 
      values < 0.05 were considered statistically significant. RESULTS: We found 
      possible association between the course of HCV infection and specific HLA 
      alleles. HLA class I CwFNx016 and HLA class II DRBFNx0110 alleles were observed 
      more frequently in the viral clearance group (P < 0.05). The HLA class I BFNx0138 
      allele group was more prone to develop chronic hepatitis C (P < 0.01). 
      CONCLUSIONS: These findings suggest that HLA class I CwFNx016 and HLA class II 
      DRBFNx0110 alleles may be associated with immunological elimination of HCV in 
      Turkish patients on hemodialysis. HLA sub-typing could help predict the prognosis 
      of HCV infection.
FAU - Ocal, Serkan
AU  - Ocal S
AD  - Department of Gastroenterology, Baskent University, Faculty of Medicine, Ankara, 
      Turkey.
FAU - Selcuk, Haldun
AU  - Selcuk H
FAU - Korkmaz, Murat
AU  - Korkmaz M
FAU - Altun, Reskan
AU  - Altun R
FAU - Yildirim, Abdullah E
AU  - Yildirim AE
FAU - Akbas, Enver
AU  - Akbas E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - Saudi J Gastroenterol
JT  - Saudi journal of gastroenterology : official journal of the Saudi 
      Gastroenterology Association
JID - 9516979
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Chi-Square Distribution
MH  - Cohort Studies
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Hepacivirus/*immunology
MH  - Hepatitis C/epidemiology/*immunology
MH  - Humans
MH  - Incidence
MH  - Kidney Failure, Chronic/diagnosis/epidemiology/*immunology/virology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sex Factors
MH  - Statistics, Nonparametric
MH  - Turkey
MH  - Viral Load/*immunology
PMC - PMC4067914
COIS- Conflict of Interest: None declared.
EDAT- 2014/07/01 06:00
MHDA- 2015/03/31 06:00
PMCR- 2014/05/01
CRDT- 2014/07/01 06:00
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - SaudiJGastroenterol_2014_20_3_175_133007 [pii]
AID - SJG-20-175 [pii]
AID - 10.4103/1319-3767.133007 [doi]
PST - ppublish
SO  - Saudi J Gastroenterol. 2014 May-Jun;20(3):175-81. doi: 10.4103/1319-3767.133007.