PMID- 24976376
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20220419
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 31
IP  - 10
DP  - 2014 Nov
TI  - Left atrial appendage aneurysm: a systematic review of 82 cases.
PG  - 1312-8
LID - 10.1111/echo.12667 [doi]
AB  - BACKGROUND: Aneurysm of the left atrial appendage is rare. We sought to 
      systematically review the published literature on left atrial appendage aneurysm 
      (LAAA) to address its demographic features, clinical characteristics, treatment, 
      complications, and outcomes. METHODOLOGY: A systematic electronic search of 
      Medline, PubMed, and EMBASE for case reports, case series, and related articles 
      of LAAA published from 1962 until July 2013 was carried out. Statistical analysis 
      was done using SPSS version 20.0. Logistic Regression Analysis was used to 
      identify the independent predictors of LAAA-related thrombus formation and 
      embolism. RESULTS: Eighty-two cases of LAAA were identified. There was a slight 
      female preponderance and most of the patients presented in their third decades. 
      Palpitation, dyspnea or both were most common clinical symptoms associated with 
      LAAA. Echocardiography was the main diagnostic modality used and the mean size of 
      aneurysm was 7.08 +/- 3.03 x 5.75 +/- 2.36 cm. Surgical resection of the aneurysm was 
      performed in most patients with favorable results. Systemic embolism and atrial 
      tachyarrhythmias were the two common complications associated with untreated 
      LAAA. Presence of atrial fibrillation/flutter was the only significant predictor 
      of thrombus formation/embolic events. CONCLUSION: Aneurysm of left atrial 
      appendage is rare and often an incidental diagnosis during echocardiography. It 
      is important to recognize this entity since it is associated with cardiovascular 
      morbidity and mortality by predisposing to atrial tachyarrhythmia and 
      thromboembolism. Surgical resection is the standard of treatment in the current 
      literature. Medical management is directed toward the treatment of 
      thromboembolism and atrial tachyarrhythmia.
CI  - (c) 2014, Wiley Periodicals, Inc.
FAU - Aryal, Madan Raj
AU  - Aryal MR
AD  - Department of Internal Medicine, Reading Health System, West Reading, 
      Pennsylvania.
FAU - Hakim, Fayaz A
AU  - Hakim FA
FAU - Ghimire, Sailu
AU  - Ghimire S
FAU - Ghimire, Sushil
AU  - Ghimire S
FAU - Giri, Smith
AU  - Giri S
FAU - Pandit, Anil
AU  - Pandit A
FAU - Bhandari, Yashoda
AU  - Bhandari Y
FAU - Bhandari, Naresh
AU  - Bhandari N
FAU - Pathak, Ranjan
AU  - Pathak R
FAU - Karmacharya, Paras
AU  - Karmacharya P
FAU - Pradhan, Rajesh
AU  - Pradhan R
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20140628
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Atrial Appendage/*diagnostic imaging/physiopathology
MH  - Cardiac Surgical Procedures/methods/mortality
MH  - Echocardiography, Transesophageal/*methods
MH  - Female
MH  - Heart Aneurysm/*diagnostic imaging/*mortality/surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Survival Analysis
MH  - Young Adult
OTO - NOTNLM
OT  - aneurysectomy
OT  - atrial tachyarrhythmia
OT  - echocardiogram
OT  - left atrial appendage aneurysm
OT  - thromboebolism
EDAT- 2014/07/01 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/07/01 06:00
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.1111/echo.12667 [doi]
PST - ppublish
SO  - Echocardiography. 2014 Nov;31(10):1312-8. doi: 10.1111/echo.12667. Epub 2014 Jun 
      28.