PMID- 24976419
OWN - NLM
STAT- MEDLINE
DCOM- 20150407
LR  - 20211203
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 30
IP  - 9
DP  - 2014 Sep
TI  - Mammalian target of rapamycin coordinates iron metabolism with iron-sulfur 
      cluster assembly enzyme and tristetraprolin.
PG  - 968-74
LID - S0899-9007(14)00034-3 [pii]
LID - 10.1016/j.nut.2013.12.016 [doi]
AB  - Both iron deficiency and excess are relatively common health concerns. 
      Maintaining the body's levels of iron within precise boundaries is critical for 
      cell functions. However, the difference between iron deficiency and overload is 
      often a question of a scant few milligrams of iron. The mammalian target of 
      rapamycin (mTOR), an atypical Ser/Thr protein kinase, is attracting significant 
      amounts of interest due to its recently described role in iron homeostasis. 
      Despite extensive study, a complete understanding of mTOR function has remained 
      elusive. mTOR can form two multiprotein complexes that consist of mTOR complex 1 
      (mTORC1) and mTOR complex 2. Recent advances clearly demonstrate that mTORC1 can 
      phosphorylate iron-sulfur cluster assembly enzyme ISCU and affect iron-sulfur 
      clusters assembly. Moreover, mTOR is reported to control iron metabolism through 
      modulation of tristetraprolin expression. It is now well appreciated that the 
      hormonal hepcidin-ferroportin system and the cellular iron-responsive 
      element/iron-regulatory protein regulatory network play important regulatory 
      roles for systemic iron metabolism. Sustained ISCU protein levels enhanced by 
      mTORC1 can inhibit iron-responsive element and iron-regulatory protein binding 
      activities. In this study, hepcidin gene and protein expression in the livers of 
      tristetraprolin knockout mice were dramatically reduced. Here, we highlight and 
      summarize the current understanding of how mTOR pathways serve to modulate iron 
      metabolism and homeostasis as the third iron-regulatory system.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Guan, Peng
AU  - Guan P
AD  - Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei 
      Province, Hebei Normal University, Hebei Province, China.
FAU - Wang, Na
AU  - Wang N
AD  - Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei 
      Province, Hebei Normal University, Hebei Province, China; School of Basic Medical 
      Sciences, Hebei University of Traditional Chinese Medicine, Hebei Province, 
      China. Electronic address: Wangna9@tom.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140110
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Iron-Sulfur Proteins)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Tristetraprolin)
RN  - 70FD1KFU70 (Sulfur)
RN  - E1UOL152H7 (Iron)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Homeostasis
MH  - Humans
MH  - Iron/*metabolism
MH  - Iron Metabolism Disorders/*metabolism
MH  - Iron-Sulfur Proteins/*metabolism
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Multiprotein Complexes/metabolism
MH  - Sulfur/metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Tristetraprolin/*metabolism
OTO - NOTNLM
OT  - Iron
OT  - Iron-sulfur clusters
OT  - Rapamycin
OT  - Transferrin receptor
OT  - Tristetraprolin
EDAT- 2014/07/01 06:00
MHDA- 2015/04/08 06:00
CRDT- 2014/07/01 06:00
PHST- 2013/10/18 00:00 [received]
PHST- 2013/12/13 00:00 [revised]
PHST- 2013/12/15 00:00 [accepted]
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2015/04/08 06:00 [medline]
AID - S0899-9007(14)00034-3 [pii]
AID - 10.1016/j.nut.2013.12.016 [doi]
PST - ppublish
SO  - Nutrition. 2014 Sep;30(9):968-74. doi: 10.1016/j.nut.2013.12.016. Epub 2014 Jan 
      10.