PMID- 24976647
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0033-2933 (Print)
IS  - 0033-2933 (Linking)
VI  - 64
IP  - 2
DP  - 2014 Jun 1
TI  - Repeated Acquisition in the Morris Swim Task: Effects of MDMA, Methamphetamine 
      and Methylphenidate.
PG  - 143-150
AB  - Acute effects of methylenedioxymethamphetamine (MDMA), methamphetamine (MA) and 
      methylphenidate (MPD) were studied using a within-subject, repeated 
      acquisition/performance procedure adapted to the Morris Swim Task. To investigate 
      place learning, the acquisition component consisted of a hidden platform that 
      varied in location across experimental sessions. As a control for drug effects 
      not specific to acquisition, a performance component was included in which the 
      hidden platform was in the same pool location in every experimental session. All 
      three drugs increased escape latencies and swim distances in dose-dependent 
      fashion. However, impairment in the acquisition component was generally observed 
      only at doses that also produced impairment in the performance component, 
      suggesting that effects were not selective to place learning. None of the drugs 
      produced enhancement of learning or performance at any dose. Taken together, the 
      results suggest that acute exposure to these psychomotor stimulants produce 
      global impairment of performance in the Morris task, rather than specific 
      deficits in place learning.
FAU - Galizio, Mark
AU  - Galizio M
AD  - Department of Psychology, University of North Carolina Wilmington.
FAU - Byrd, Bridget D
AU  - Byrd BD
AD  - Department of Psychology, University of North Carolina Wilmington.
FAU - Robinson, Andrea M
AU  - Robinson AM
AD  - Department of Psychology, University of North Carolina Wilmington.
FAU - Hawkey, Andrew
AU  - Hawkey A
AD  - Department of Psychology, University of North Carolina Wilmington.
FAU - Rayburn-Reeves, Rebecca
AU  - Rayburn-Reeves R
AD  - Department of Psychology, University of North Carolina Wilmington.
FAU - April, L Brooke
AU  - April LB
AD  - Department of Psychology, University of North Carolina Wilmington.
LA  - eng
GR  - R15 DA012879/DA/NIDA NIH HHS/United States
GR  - R15 DA029252/DA/NIDA NIH HHS/United States
PT  - Journal Article
PL  - Switzerland
TA  - Psychol Rec
JT  - The Psychological record
JID - 0243242
PMC - PMC4066990
MID - NIHMS582360
OTO - NOTNLM
OT  - MDMA
OT  - Methamphetamine
OT  - Methylphenidate
OT  - Morris Swim Task
OT  - Spatial Learning
EDAT- 2014/07/01 06:00
MHDA- 2014/07/01 06:01
PMCR- 2015/06/01
CRDT- 2014/07/01 06:00
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2014/07/01 06:01 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - 10.1007/s40732-014-0023-1 [doi]
PST - ppublish
SO  - Psychol Rec. 2014 Jun 1;64(2):143-150. doi: 10.1007/s40732-014-0023-1.