PMID- 24976758
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140630
LR  - 20211021
IS  - 1226-4512 (Print)
IS  - 2093-3827 (Electronic)
IS  - 1226-4512 (Linking)
VI  - 18
IP  - 3
DP  - 2014 Jun
TI  - Alpha-Asarone, a Major Component of Acorus gramineus, Attenuates 
      Corticosterone-Induced Anxiety-Like Behaviours via Modulating TrkB Signaling 
      Process.
PG  - 191-200
LID - 10.4196/kjpp.2014.18.3.191 [doi]
AB  - We investigated the anxiolytic-like activity of alpha-asarone (AAS) from Acorus 
      gramineus in an experimental rat model of anxiety induced by repeated 
      administration of the exogenous stress hormone corticosterone (CORT). The 
      putative anxiolytic effect of AAS was studied in behavioral tests of anxiety, 
      such as the elevated plus maze (EPM) test and the hole-board test (HBT) in rats. 
      For 21 consecutive days, male rats received 50, 100, or 200 mg/kg AAS (i.p.) 30 
      min prior to a daily injection of CORT. Dysregulation of the HPA axis in response 
      to the repeated CORT injections was confirmed by measuring serum levels of CORT 
      and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. 
      Daily AAS (200 mg/kg) administration increased open-arm exploration significantly 
      in the EPM test, and it increased the duration of head dipping activity in the 
      HBT. It also blocked the increase in tyrosine hydroxylase (TH) expression in the 
      locus coeruleus (LC) and decreased mRNA expression of brain-derived neurotrophic 
      factor (BDNF) and its receptor, TrkB, in the hippocampus. These results indicated 
      that the administration of AAS prior to high-dose exogenous CORT significantly 
      improved anxiety-like behaviors, which are associated with modification of the 
      central noradrenergic system and with BDNF function in rats. The current finding 
      may improve understanding of the neurobiological mechanisms responsible for 
      changes in emotions induced by repeated administration of high doses of CORT or 
      by elevated levels of hormones associated with chronic stress. Thus, AAS did 
      exhibit an anxiolytic-like effects in animal models of anxiety.
FAU - Lee, Bombi
AU  - Lee B
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, Seoul 130-701, Korea.
FAU - Sur, Bongjun
AU  - Sur B
AD  - The Graduate School of Basic Science of Korean Medicine, College of Korean 
      Medicine, Kyung Hee University, Seoul 130-701, Korea.
FAU - Yeom, Mijung
AU  - Yeom M
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, Seoul 130-701, Korea.
FAU - Shim, Insop
AU  - Shim I
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, Seoul 130-701, Korea. ; The Graduate School of Basic 
      Science of Korean Medicine, College of Korean Medicine, Kyung Hee University, 
      Seoul 130-701, Korea.
FAU - Lee, Hyejung
AU  - Lee H
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, Seoul 130-701, Korea. ; The Graduate School of Basic 
      Science of Korean Medicine, College of Korean Medicine, Kyung Hee University, 
      Seoul 130-701, Korea.
FAU - Hahm, Dae-Hyun
AU  - Hahm DH
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, Seoul 130-701, Korea. ; The Graduate School of Basic 
      Science of Korean Medicine, College of Korean Medicine, Kyung Hee University, 
      Seoul 130-701, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140612
PL  - Korea (South)
TA  - Korean J Physiol Pharmacol
JT  - The Korean journal of physiology & pharmacology : official journal of the Korean 
      Physiological Society and the Korean Society of Pharmacology
JID - 9709505
PMC - PMC4071171
OTO - NOTNLM
OT  - Anxiety
OT  - Brain-derived neurotrophic factor
OT  - Corticosterone
OT  - Tyrosine hydroxylase
OT  - alpha-asarone
EDAT- 2014/07/01 06:00
MHDA- 2014/07/01 06:01
PMCR- 2014/06/01
CRDT- 2014/07/01 06:00
PHST- 2013/12/27 00:00 [received]
PHST- 2014/03/18 00:00 [revised]
PHST- 2014/04/12 00:00 [accepted]
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2014/07/01 06:01 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - 10.4196/kjpp.2014.18.3.191 [doi]
PST - ppublish
SO  - Korean J Physiol Pharmacol. 2014 Jun;18(3):191-200. doi: 
      10.4196/kjpp.2014.18.3.191. Epub 2014 Jun 12.