PMID- 24977116 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140630 LR - 20211021 IS - 2220-315X (Print) IS - 2220-315X (Electronic) IS - 2220-315X (Linking) VI - 4 IP - 1 DP - 2014 Feb 20 TI - High density lipoproteins and type 2 diabetes: Emerging concepts in their relationship. PG - 1-6 LID - 10.5493/wjem.v4.i1.1 [doi] AB - Patients with type 2 diabetes mellitus (T2DM) frequently exhibit macrovascular complications of atherosclerotic cardiovascular (CV) disease. High density lipoproteins (HDL) are protective against atherosclerosis. Low levels of HDL cholesterol (HDL-C) independently contribute to CV risk. Patients with T2DM not only exhibit low HDL-C, but also dysfunctional HDL. Furthermore, low concentration of HDL may increase the risk for the development of T2DM through a decreased beta cell survival and secretory function. In this paper, we discuss emerging concepts in the relationship of T2DM with HDL. FAU - Kostapanos, Michael S AU - Kostapanos MS AD - Michael S Kostapanos, Moses S Elisaf, Department of Internal Medicine, School of Medicine, University of Ioannina, 45110 Ioannina, Greece. FAU - Elisaf, Moses S AU - Elisaf MS AD - Michael S Kostapanos, Moses S Elisaf, Department of Internal Medicine, School of Medicine, University of Ioannina, 45110 Ioannina, Greece. LA - eng PT - Journal Article DEP - 20140220 PL - United States TA - World J Exp Med JT - World journal of experimental medicine JID - 101618808 PMC - PMC4073260 OTO - NOTNLM OT - High density lipoproteins OT - Insulin secretion OT - Paraoxonase-1 OT - Type 2 diabetes OT - beta cells EDAT- 2014/07/01 06:00 MHDA- 2014/07/01 06:01 PMCR- 2014/02/20 CRDT- 2014/07/01 06:00 PHST- 2013/10/30 00:00 [received] PHST- 2013/11/11 00:00 [revised] PHST- 2013/11/15 00:00 [accepted] PHST- 2014/07/01 06:00 [entrez] PHST- 2014/07/01 06:00 [pubmed] PHST- 2014/07/01 06:01 [medline] PHST- 2014/02/20 00:00 [pmc-release] AID - 10.5493/wjem.v4.i1.1 [doi] PST - epublish SO - World J Exp Med. 2014 Feb 20;4(1):1-6. doi: 10.5493/wjem.v4.i1.1. eCollection 2014 Feb 20.