PMID- 24977240
OWN - NLM
STAT- MEDLINE
DCOM- 20150604
LR  - 20211021
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 2014
DP  - 2014
TI  - Mycoplasma pneumoniae infection in children is a risk factor for developing 
      allergic diseases.
PG  - 986527
LID - 10.1155/2014/986527 [doi]
LID - 986527
AB  - Mycoplasma pneumoniae (MP) infection is the dominant cause of pneumonia in 
      children. We sought to determine the relationship between MP infection and 
      secondary allergic disease and to clarify the associated mechanisms of 
      inflammatory response. A prospective study was performed among 1330 patients 
      diagnosed with pneumonia to investigate the patient immune status by determining 
      the correlation between MP infection, immunoglobulin E (IgE) levels, and a 
      spectrum of associated serum cytokines. Serum IgE, IL-4, IL-6, and IL-10 levels 
      for MPP patients in the acute phase were obviously higher than those in the 
      recovery phase (P < 0.01). MPP patients with allergic conditions had increased 
      serum IgE levels and increased IL-4/INF- gamma ratio, and IgE and Eosinophil Cationic 
      Protein were further elevated in patients who eventually developed secondary 
      asthma changes. Patients with severe pneumonia and high clinical pulmonary 
      infection scores presented higher levels of IL-4 and IL-5 in serum than those 
      with low scores (P < 0.01). The proportion of CD4+ and CD8+ T cells that secreted 
      IL-4 was significantly increased in MPP patients with elevated IgE. Our data 
      demonstrate a significant correlation between MP infection and IgE levels, which 
      is associated with a Th1/Th2 cytokine imbalance.
FAU - Ye, Qing
AU  - Ye Q
AD  - Clinical Laboratory, The Children's Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310003, China.
FAU - Xu, Xiao-Jun
AU  - Xu XJ
AD  - The Department of Hematology/Oncology, The Children's Hospital of Zhejiang 
      University School of Medicine, Hangzhou 310003, China.
FAU - Shao, Wen-Xia
AU  - Shao WX
AD  - Clinical Laboratory, Hangzhou First People's Hospital, Hangzhou 310003, China.
FAU - Pan, Yan-Xiang
AU  - Pan YX
AD  - Clinical Laboratory, The Children's Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310003, China.
FAU - Chen, Xue-Jun
AU  - Chen XJ
AD  - Clinical Laboratory, The Children's Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310003, China.
LA  - eng
PT  - Journal Article
DEP - 20140407
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/blood
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*blood/diagnosis/*epidemiology
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Pneumonia, Mycoplasma/*blood/diagnosis/*epidemiology
MH  - Prevalence
MH  - Risk Factors
PMC - PMC3996910
EDAT- 2014/07/01 06:00
MHDA- 2015/06/05 06:00
PMCR- 2014/04/07
CRDT- 2014/07/01 06:00
PHST- 2014/01/07 00:00 [received]
PHST- 2014/02/16 00:00 [accepted]
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2015/06/05 06:00 [medline]
PHST- 2014/04/07 00:00 [pmc-release]
AID - 10.1155/2014/986527 [doi]
PST - ppublish
SO  - ScientificWorldJournal. 2014;2014:986527. doi: 10.1155/2014/986527. Epub 2014 Apr 
      7.