PMID- 24977434
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20181202
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 19
IP  - 4
DP  - 2014 Aug
TI  - Acceptable mismatching at the class II epitope level: the Canadian experience.
PG  - 442-6
LID - 10.1097/MOT.0000000000000104 [doi]
AB  - PURPOSE OF REVIEW: To summarize the evidence concerning human leukocyte antigen 
      (HLA) epitope mismatch analysis as a means to predict donor-specific antibody 
      (DSA) development and allograft survival. RECENT FINDINGS: HLA epitope mismatch 
      analysis outperforms traditional whole molecule antigen mismatch for predicting 
      the risk of de-novo DSA development. By analyzing the number of epitope 
      mismatches for a given donor-recipient pair, thresholds have been identified to 
      stratify patients into those at high or low risk of de-novo DSA development. 
      Epitope specificity assignment in patients who develop de-novo DSA compared with 
      controls who do not provides an opportunity to study the relative immunogenicity 
      of mismatched HLA epitopes. SUMMARY: Recognizing that de-novo DSA is a major 
      cause of graft loss, HLA epitope mismatch analysis is a strategy to minimize 
      de-novo DSA development and improve long-term graft survival.
FAU - Wiebe, Chris
AU  - Wiebe C
AD  - aDepartment of Medicine and Immunology, University of Manitoba bDiagnostic 
      Services of Manitoba, Winnipeg, Manitoba, Canada.
FAU - Nickerson, Peter
AU  - Nickerson P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Antibodies)
RN  - 0 (Epitopes)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Antibodies/immunology
MH  - Canada
MH  - Epitopes/*immunology
MH  - Graft Survival/immunology
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Transplantation, Homologous
EDAT- 2014/07/01 06:00
MHDA- 2015/01/21 06:00
CRDT- 2014/07/01 06:00
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
AID - 10.1097/MOT.0000000000000104 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2014 Aug;19(4):442-6. doi: 
      10.1097/MOT.0000000000000104.