PMID- 24977435
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20211021
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Print)
IS  - 1087-2418 (Linking)
VI  - 19
IP  - 4
DP  - 2014 Aug
TI  - Human leukocyte antigen Bw4 and Bw6 epitopes recognized by antibodies and natural 
      killer cells.
PG  - 436-41
LID - 10.1097/MOT.0000000000000103 [doi]
AB  - PURPOSE OF REVIEW: To describe the structural basis of human leukocyte antigen 
      (HLA) Bw4 and Bw6 epitopes that are recognized by antibodies and the KIR3DL1 
      natural killer cell receptor. RECENT FINDINGS: Molecular modeling and X-ray 
      crystallography have refined our understanding of Bw4 and Bw6. These epitopes had 
      been defined by comparison of HLA allele sequences and by site-directed 
      mutagenesis. Anti-Bw4 and anti-Bw6 antibodies and KIR3DL1 receptors recognize HLA 
      alpha-1 alpha-helix residues 77-83 in combination with other HLA regions. The variability 
      of HLA sequences within the 77-83 region and at other sites indicates that the 
      Bw4 epitope is complex. Adding complexity, HLA-bound peptides influence Bw4 and 
      Bw6 epitopes. These structures are recognized by diverse antibodies and KIR3DL1 
      allotypes. This diversity allowed a Bw4 patient to produce anti-Bw4 antibody 
      without breaking self-tolerance. SUMMARY: Bw4 and Bw6 epitopes are best regarded 
      as families of related structures that are recognized by a diverse array of 
      antibodies and KIR3DL1 allotypes.
FAU - Lutz, Charles T
AU  - Lutz CT
AD  - Department of Pathology and Laboratory Medicine and Department of Microbiology, 
      Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, 
      USA.
LA  - eng
GR  - R01 AI050656/AI/NIAID NIH HHS/United States
GR  - R01 AI56506/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Antibodies)
RN  - 0 (Epitopes)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-Bw4 antigen)
RN  - 0 (HLA-Bw6 antigen)
SB  - IM
MH  - Antibodies/*immunology
MH  - Epitopes/*immunology
MH  - HLA-B Antigens/*immunology
MH  - Humans
MH  - Killer Cells, Natural/*immunology
PMC - PMC5742561
MID - NIHMS634456
COIS- Conflict of Interest: The author declares no conflicts of interest.
EDAT- 2014/07/01 06:00
MHDA- 2015/01/21 06:00
PMCR- 2017/12/25
CRDT- 2014/07/01 06:00
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
PHST- 2017/12/25 00:00 [pmc-release]
AID - 10.1097/MOT.0000000000000103 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2014 Aug;19(4):436-41. doi: 
      10.1097/MOT.0000000000000103.