PMID- 24977436
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20181202
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 19
IP  - 4
DP  - 2014 Aug
TI  - Structural and electrostatic analysis of HLA B-cell epitopes: inference on 
      immunogenicity and prediction of humoral alloresponses.
PG  - 420-7
LID - 10.1097/MOT.0000000000000108 [doi]
AB  - PURPOSE OF REVIEW: The immunogenic capacity of donor human leukocyte antigen 
      (HLA) to induce humoral immune responses is not an intrinsic property of the 
      mismatched alloantigen but depends on the HLA phenotype of the recipient. In 
      recent years, advances in molecular sequence technology and information from 
      X-ray crystallography have enabled structural comparison of donor and recipient 
      HLA type providing an opportunity for a more rational approach for determining 
      HLA compatibility. In this article, we review studies investigating the molecular 
      basis of antibody-antigen interactions and present computational approaches to 
      determine the complex physiochemical and structural properties of B-cell 
      epitopes. RECENT FINDINGS: The relative immunogenicity of individual HLA 
      mismatches may be predicted from analysis of polymorphic amino acids at 
      continuous and discontinuous HLA sequence positions. The use of alloantigen 
      sequence information alone, however, provides limited insight into key 
      determinants of B-cell epitope immunogenicity, such as the orientation, 
      accessibility and physiochemical properties of amino acid side chains. Advances 
      in computational molecular modelling techniques now enable assessment of 
      HLA-alloantibody interactions at the atomic level. Recent evidence supports a 
      strong link between HLA B-cell epitope surface electrostatic potential and their 
      immunogenicity. SUMMARY: Assessment of the surface electrostatic properties of 
      HLA alloantigens and computational analyses of HLA-alloantibody interactions 
      represent a promising area for future research into the molecular basis of HLA 
      immunogenicity and antigenicity.
FAU - Mallon, Dermot H
AU  - Mallon DH
AD  - aDepartment of Surgery, University of Cambridge, and NIHR Cambridge Biomedical 
      Research Centre bTissue Typing Laboratory, Cambridge University Hospitals NHS 
      Foundation Trust, Addenbrooke's Hospital, Cambridge, UK.
FAU - Bradley, J A
AU  - Bradley JA
FAU - Taylor, Craig J
AU  - Taylor CJ
FAU - Kosmoliaptsis, Vasilis
AU  - Kosmoliaptsis V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Epitopes, B-Lymphocyte)
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantigens)
SB  - IM
MH  - Antibody Formation/immunology
MH  - Epitopes, B-Lymphocyte/*immunology
MH  - HLA Antigens/chemistry/genetics/*immunology
MH  - Humans
MH  - Immunity, Innate
MH  - Isoantigens/immunology
MH  - Static Electricity
EDAT- 2014/07/01 06:00
MHDA- 2015/01/21 06:00
CRDT- 2014/07/01 06:00
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
AID - 10.1097/MOT.0000000000000108 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2014 Aug;19(4):420-7. doi: 
      10.1097/MOT.0000000000000108.