PMID- 24977479
OWN - NLM
STAT- MEDLINE
DCOM- 20150220
LR  - 20190212
IS  - 1421-9778 (Electronic)
IS  - 1015-8987 (Linking)
VI  - 34
IP  - 1
DP  - 2014
TI  - Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory 
      effects in vitro and in vivo.
PG  - 27-44
LID - 10.1159/000362982 [doi]
AB  - Dendritic cells (DCs) are the cutting edge in innate and adaptive immunity. The 
      major functions of these antigen-presenting cells are the capture, endosomal 
      processing and presentation of antigens, providing them an exclusive ability to 
      provoke adaptive immune responses and to induce and control tolerance. Immature 
      DCs capture and process antigens, migrate towards secondary lymphoid organs where 
      they present antigens to naive T cells in a well-synchronized sequence of 
      procedures referred to as maturation. Indeed, recent research indicated that 
      sphingolipids are modulators of essential steps in DC homeostasis. It has been 
      recognized that sphingolipids not only modulate the development of DC subtypes 
      from precursor cells but also influence functional activities of DCs such as 
      antigen capture, and cytokine profiling. Thus, it is not astonishing that 
      sphingolipids and sphingolipid metabolism play a substantial role in inflammatory 
      diseases that are modulated by DCs. Here we highlight the function of sphingosine 
      1-phosphate (S1P) on DC homeostasis and the role of S1P and S1P metabolism in 
      inflammatory diseases.
FAU - Arlt, Olga
AU  - Arlt O
AD  - Pharmazentrum Frankfurt/ZAFES, Clinic of the Goethe University, Frankfurt, 
      Germany.
FAU - Schwiebs, Anja
AU  - Schwiebs A
FAU - Japtok, Lukasz
AU  - Japtok L
FAU - Ruger, Katja
AU  - Ruger K
FAU - Katzy, Elisabeth
AU  - Katzy E
FAU - Kleuser, Burkhard
AU  - Kleuser B
FAU - Radeke, Heinfried H
AU  - Radeke HH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140616
PL  - Germany
TA  - Cell Physiol Biochem
JT  - Cellular physiology and biochemistry : international journal of experimental 
      cellular physiology, biochemistry, and pharmacology
JID - 9113221
RN  - 0 (Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Lysophospholipids)
RN  - 0 (Toll-Like Receptors)
RN  - 26993-30-6 (sphingosine 1-phosphate)
RN  - NGZ37HRE42 (Sphingosine)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Antigens/immunology
MH  - Cytokines/metabolism
MH  - Dendritic Cells/immunology/*metabolism
MH  - Humans
MH  - Immunity, Innate
MH  - Lysophospholipids/*metabolism
MH  - Skin Diseases/immunology/metabolism/pathology
MH  - Sphingosine/*analogs & derivatives/metabolism
MH  - Toll-Like Receptors/metabolism
MH  - Transcriptome
EDAT- 2014/07/01 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/07/01 06:00
PHST- 2014/05/01 00:00 [accepted]
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - 000362982 [pii]
AID - 10.1159/000362982 [doi]
PST - ppublish
SO  - Cell Physiol Biochem. 2014;34(1):27-44. doi: 10.1159/000362982. Epub 2014 Jun 16.