PMID- 24977975
OWN - NLM
STAT- MEDLINE
DCOM- 20141229
LR  - 20180816
IS  - 0172-780X (Print)
IS  - 0172-780X (Linking)
VI  - 35
IP  - 3
DP  - 2014
TI  - Associations between brain-derived neurotrophic factor and estradiol in women's 
      saliva.
PG  - 236-41
AB  - OBJECTIVE: The aim of this study was to assess the relationship between 
      brain-derived neurotrophic factor (BDNF) and sex hormones (estradiol [E2] and 
      progesterone), using saliva samples obtained from healthy women. METHODS: Forty 
      female dental hygienist students were divided into groups according to being in 
      the follicular phase or luteal phase. Saliva BDNF, E2, and progesterone levels 
      were measured using a sandwich ELISA system. The correlation between these 
      factors was analyzed using Spearman's index, and fluctuations of these levels in 
      the whole menstrual cycle were investigated classifying the subjects by every 4 
      days according to the phase of their menstrual cycle. RESULTS: Saliva BDNF 
      variations strongly correlated with saliva E2 levels in the follicular phase (r = 
      0.721, p = 0.000) and luteal phase (r = 0.770, p = 0.000). The correlation 
      coefficient showing the relationship between progesterone and BDNF levels in the 
      luteal phase (r = 0.371, p = 0.157) was lower than that in the follicular phase 
      (r = 0.631, p = 0.001). Moreover, the fluctuation of BDNF levels in the menstrual 
      cycle followed a similar pattern to that of E2. CONCLUSIONS: We found that saliva 
      BDNF and E2 levels were closely related in healthy young women. In particular, 
      for first time, that correlation was investigated throughout the menstrual cycle. 
      Monitoring of saliva BDNF may yield insight into women's reproductive and mental 
      health.
FAU - Matsuki, Chisa
AU  - Matsuki C
FAU - To, Masahiro
AU  - To M
FAU - Kondo, Yusuke
AU  - Kondo Y
FAU - Sugiyama, Hiroki
AU  - Sugiyama H
FAU - Yamamoto, Yuko
AU  - Yamamoto Y
FAU - Shimizu, Tomoko
AU  - Shimizu T
FAU - Kamata, Yohei
AU  - Kamata Y
FAU - Saruta, Juri
AU  - Saruta J
FAU - Tsukinoki, Keiichi
AU  - Tsukinoki K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Estradiol/*metabolism
MH  - Female
MH  - Follicular Phase/metabolism
MH  - Humans
MH  - Luteal Phase/metabolism
MH  - Monitoring, Physiologic
MH  - Progesterone/metabolism
MH  - Saliva/*metabolism
MH  - Young Adult
EDAT- 2014/07/01 06:00
MHDA- 2014/12/30 06:00
CRDT- 2014/07/01 06:00
PHST- 2014/06/05 00:00 [received]
PHST- 2014/06/12 00:00 [accepted]
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
AID - NEL350314A06 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2014;35(3):236-41.