PMID- 24978398
OWN - NLM
STAT- MEDLINE
DCOM- 20150224
LR  - 20140709
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 25
IP  - 12
DP  - 2014 Aug 20
TI  - Effects of the neurotrophic factors BDNF, NT-3, and FGF2 on dissociated neurons 
      of the cochlear nucleus.
PG  - 960-4
LID - 10.1097/WNR.0000000000000220 [doi]
AB  - The cochlear nucleus is the first relay station for acoustic information in the 
      auditory pathway and its cellular integrity is affected by hearing loss. 
      Neurotrophic factors, which are known to regulate fundamental processes in the 
      brain, are expressed in the cochlear nucleus and are regulated by the changes in 
      the stimulation. The aim of this study was to evaluate the effect of the 
      neurotrophins Brain derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) 
      and the neurotrophic factor Fibroblast growth factor 2 (FGF2) on primary cultured 
      cells of the mouse cochlear nucleus. No effect on overall cell growth was 
      detected after 8 days in culture by the factors applied. NT-3 had a strong impact 
      on enhancement of neuronal survival, whereas BDNF stimulated neuronal survival 
      and axonal outgrowth. Axonal branching was negatively affected by the 
      administration of BDNF. FGF2 did not show any effect. The results presented 
      represent fundamental research on auditory neurons, but might be one step toward 
      defining novel therapeutic strategies in the future to prevent cochlear nucleus 
      degeneration induced by hearing loss.
FAU - Rak, Kristen
AU  - Rak K
AD  - aDepartment of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head 
      and Neck Surgery, Comprehensive Hearing Center bInstitute for Clinical 
      Neurobiology, University of Wuerzburg, Wuerzburg, Germany.
FAU - Volker, Johannes
AU  - Volker J
FAU - Frenz, Silke
AU  - Frenz S
FAU - Scherzad, Agmal
AU  - Scherzad A
FAU - Schendzielorz, Philipp
AU  - Schendzielorz P
FAU - Radeloff, Andreas
AU  - Radeloff A
FAU - Jablonka, Sibylle
AU  - Jablonka S
FAU - Hagen, Rudolf
AU  - Hagen R
FAU - Mlynski, Robert
AU  - Mlynski R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (neurotropin 3, mouse)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Animals
MH  - Axons/physiology
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cell Enlargement
MH  - Cell Survival/physiology
MH  - Cells, Cultured
MH  - Cochlear Nucleus/cytology/*physiology
MH  - Fibroblast Growth Factor 2/*metabolism
MH  - Immunohistochemistry
MH  - Mice
MH  - Nerve Growth Factors/*metabolism
MH  - Neurons/cytology/*physiology
EDAT- 2014/07/01 06:00
MHDA- 2015/02/25 06:00
CRDT- 2014/07/01 06:00
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2015/02/25 06:00 [medline]
AID - 10.1097/WNR.0000000000000220 [doi]
PST - ppublish
SO  - Neuroreport. 2014 Aug 20;25(12):960-4. doi: 10.1097/WNR.0000000000000220.