PMID- 24978930
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20140815
IS  - 1098-2396 (Electronic)
IS  - 0887-4476 (Linking)
VI  - 68
IP  - 10
DP  - 2014 Oct
TI  - Evaluation of NCS-1, DARPP-32, and neurotrophins in hippocampus and prefrontal 
      cortex in rats submitted to sepsis.
PG  - 474-9
LID - 10.1002/syn.21760 [doi]
AB  - Sepsis is defined as the host's reaction to infection and it is characterized by 
      a systemic inflammatory response with important clinical implications. Central 
      nervous system dysfunction secondary to sepsis is associated with local 
      generation of pro- and anti-inflammatory cytokines, impaired cerebral 
      microcirculation, disturbance of neurotransmitters, apoptosis, and cognitive 
      impairment. It is known that during the process of learning and memory formation 
      several pathways are involved such as dopaminergic and cholinergic systems. Thus, 
      the objective of this study is to evaluate the neuronal calcium sensor (NCS-1) 
      and dopamine-cAMP regulated phosphoprotein of 32,000 kDa (DARPP-32) expression as 
      well as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) 
      levels in prefrontal cortex and hippocampus of rats 12, 24, and 48 h after sepsis 
      induction. To this aim, we used sham-operated Wistar rats or submitted to the 
      cecal ligation and perforation procedure. After 12 and 24 h, there was an 
      increase of NGF levels in hippocampus; and up to 48 h, a decrease of NCS-1 
      expression in prefrontal cortex, a decrease of BDNF levels in hippocampus and an 
      increase of NGF levels in hippocampus. In conclusion, we believe that the low 
      expression of NCS-1 in prefrontal cortex and low levels of BDNF in hippocampus 
      may be associated with the pathophysiology of cognitive impairment during sepsis 
      and a putative role of the dopaminergic system.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Comim, Clarissa M
AU  - Comim CM
AD  - Postgraduate Program in Health Sciences, Laboratory of Experimental 
      Neurosciences, Infectious Diseases Unit, University of South Santa Catarina, 
      Palhoca, Santa Catarina, Brazil.
FAU - Silva, Napoleao C
AU  - Silva NC
FAU - Mina, Francielle
AU  - Mina F
FAU - Dominguini, Diogo
AU  - Dominguini D
FAU - Scaini, Giselli
AU  - Scaini G
FAU - Morais, Meline O S
AU  - Morais MO
FAU - Rosa, Daniela V
AU  - Rosa DV
FAU - Magno, Luiz Alexandre V
AU  - Magno LA
FAU - Streck, Emilio L
AU  - Streck EL
FAU - Romano-Silva, Marco A
AU  - Romano-Silva MA
FAU - Quevedo, Joao
AU  - Quevedo J
FAU - Dal-Pizzol, Felipe
AU  - Dal-Pizzol F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140716
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine and cAMP-Regulated Phosphoprotein 32)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuronal Calcium-Sensor Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Ppp1r1b protein, rat)
RN  - 0 (frequenin calcium sensor proteins)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Disease Models, Animal
MH  - Dopamine and cAMP-Regulated Phosphoprotein 32/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/*metabolism
MH  - Immunoblotting
MH  - Male
MH  - Nerve Growth Factor/metabolism
MH  - Nerve Growth Factors/*metabolism
MH  - Neuronal Calcium-Sensor Proteins/*metabolism
MH  - Neuropeptides/*metabolism
MH  - Prefrontal Cortex/*metabolism
MH  - Rats, Wistar
MH  - Sepsis/*metabolism
MH  - Time Factors
OTO - NOTNLM
OT  - BDNF
OT  - NGF
OT  - brain
OT  - cognitive impairment
EDAT- 2014/07/01 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/07/01 06:00
PHST- 2014/03/31 00:00 [received]
PHST- 2014/05/15 00:00 [revised]
PHST- 2014/05/29 00:00 [accepted]
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - 10.1002/syn.21760 [doi]
PST - ppublish
SO  - Synapse. 2014 Oct;68(10):474-9. doi: 10.1002/syn.21760. Epub 2014 Jul 16.