PMID- 24979673
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 75
IP  - 8
DP  - 2014 Aug
TI  - The polymorphisms of human leukocyte antigen loci may contribute to the 
      susceptibility and severity of severe aplastic anemia in Chinese patients.
PG  - 867-72
LID - S0198-8859(14)00175-X [pii]
LID - 10.1016/j.humimm.2014.06.011 [doi]
AB  - The human leukocyte antigen (HLA) system has been reported to be involved in the 
      development of aplastic anemia (AA). We compared and analyzed HLA-A, B, C, DRB1 
      and DQB1 alleles in 96 Chinese severe AA (SAA) patients to those in 600 healthy 
      people chosen randomly from the China Marrow Donor Program to investigate the 
      association of HLA class I and II allele polymorphisms with disposition of SAA 
      and its severity degree in Chinese population. The DNA of patients was extracted 
      and HLA high-resolution genotyping was conducted using polymerase chain 
      reaction-sequence based typing technique. The gene frequencies of A( *)02:01, 
      A( *)02:06, B( *)13:01, DRB1( *)07:01, DRB1( *)09:01, DRB1( *)15:01 and DQB1( *)06:02 
      in SAA patients were significantly higher than in controls (all P<0.05), while 
      the allelic frequencies of A( *)02:07, A( *)11:01 and B( *)40:01 were notably lower 
      in SAA patients than those in the controls (P = 0.001, 0.002, 0.005, 
      respectively). Comparison among different severity of SAA groups exhibited 
      significant increases of DRB1( *)15:01 (P = 0.027) and DQB1( *)06:02 (P = 0.013), 
      but obviously lower frequencies of B( *)46:01 (P = 0.023) and DRB1( *)09:01 (P = 
      0.020) in non-VSAA patients than in VSAA patients. Thus, our results identified 
      several risk and protective HLA alleles for Chinese SAA patients. Moreover, 
      DRB1( *)15:01, DQB1( *)06:02, B( *)46:01 and DRB1( *)09:01 may be associated with 
      severity of SAA.
CI  - Copyright (c) 2014 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Wang, Min
AU  - Wang M
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood 
      Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical 
      College, 288 Nanjing Road, Tianjin 300020, PR China.
FAU - Nie, Neng
AU  - Nie N
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood 
      Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical 
      College, 288 Nanjing Road, Tianjin 300020, PR China.
FAU - Feng, Sizhou
AU  - Feng S
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood 
      Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical 
      College, 288 Nanjing Road, Tianjin 300020, PR China.
FAU - Shi, Jun
AU  - Shi J
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood 
      Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical 
      College, 288 Nanjing Road, Tianjin 300020, PR China.
FAU - Ge, Meili
AU  - Ge M
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood 
      Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical 
      College, 288 Nanjing Road, Tianjin 300020, PR China.
FAU - Li, Xingxin
AU  - Li X
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood 
      Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical 
      College, 288 Nanjing Road, Tianjin 300020, PR China.
FAU - Shao, Yingqi
AU  - Shao Y
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood 
      Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical 
      College, 288 Nanjing Road, Tianjin 300020, PR China.
FAU - Huang, Jinbo
AU  - Huang J
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood 
      Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical 
      College, 288 Nanjing Road, Tianjin 300020, PR China.
FAU - Zheng, Yizhou
AU  - Zheng Y
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood 
      Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical 
      College, 288 Nanjing Road, Tianjin 300020, PR China. Electronic address: 
      zheng_yizhou@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140627
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Anemia, Aplastic/*genetics/immunology/pathology
MH  - Asian People
MH  - Child
MH  - Disease Susceptibility
MH  - Female
MH  - Gene Frequency
MH  - HLA-A Antigens/*genetics/immunology
MH  - HLA-B Antigens/*genetics/immunology
MH  - HLA-C Antigens/*genetics/immunology
MH  - HLA-DQ beta-Chains/*genetics/immunology
MH  - HLA-DRB1 Chains/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Aplastic anemia
OT  - Chinese
OT  - HLA
OT  - Severity
OT  - Susceptibility
EDAT- 2014/07/01 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/07/01 06:00
PHST- 2013/08/08 00:00 [received]
PHST- 2014/06/19 00:00 [revised]
PHST- 2014/06/19 00:00 [accepted]
PHST- 2014/07/01 06:00 [entrez]
PHST- 2014/07/01 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - S0198-8859(14)00175-X [pii]
AID - 10.1016/j.humimm.2014.06.011 [doi]
PST - ppublish
SO  - Hum Immunol. 2014 Aug;75(8):867-72. doi: 10.1016/j.humimm.2014.06.011. Epub 2014 
      Jun 27.