PMID- 24980021
OWN - NLM
STAT- MEDLINE
DCOM- 20140722
LR  - 20140701
IS  - 0301-1208 (Print)
IS  - 0301-1208 (Linking)
VI  - 51
IP  - 2
DP  - 2014 Apr
TI  - A study on human leukocyte antigen class I molecules in paediatric bronchial 
      asthma.
PG  - 160-3
AB  - Childhood asthma, often associated with atopy, is more common in boys and may 
      persist throughout life in 50% of cases. This case-control study was carried out 
      to examine if any association of paediatric bronchial asthma with human leukocyte 
      antigen (HLA) class I antigens. Thirty-six children with bronchial asthma 
      diagnosed on basis of Global Initiative for Asthma (GINA) criteria and an equal 
      number of healthy controls without history of bronchial asthma were studied. Low 
      resolution HLA- ABC typing was performed by sequence specific primers (SSP) and 
      the frequency of HLA-ABC antigens in the two groups was compared. Total serum 
      immunoglobulin E (IgE) estimation was done as a marker of atopy by ELISA. The 
      study included 24 boys and 12 girls aged 13 months to 11 yrs, of which 16 (44%) 
      had positive family history. Serum IgE levels were elevated in 20 (55%) of the 
      cases and 33% of controls with peak values of 4877 and 627 IU/ml, respectively. 
      No statistically significant correlation was observed between childhood asthma 
      and HLA class I antigens, however, a statistically significant correlation was 
      observed between serum IgE levels and asthma, which was elevated in cases, as 
      compared to normal population. Serum IgE levels did not show a linear trend, in 
      that a direct correlation with the severity of disease was not observed.
FAU - Mishra, Mahendra N
AU  - Mishra MN
FAU - Dudeja, Puja
AU  - Dudeja P
FAU - Gupta, Rakesh K
AU  - Gupta RK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - Indian J Biochem Biophys
JT  - Indian journal of biochemistry & biophysics
JID - 0310774
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Asthma/blood/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Male
EDAT- 2014/07/02 06:00
MHDA- 2014/07/23 06:00
CRDT- 2014/07/02 06:00
PHST- 2014/07/02 06:00 [entrez]
PHST- 2014/07/02 06:00 [pubmed]
PHST- 2014/07/23 06:00 [medline]
PST - ppublish
SO  - Indian J Biochem Biophys. 2014 Apr;51(2):160-3.