PMID- 24981433
OWN - NLM
STAT- MEDLINE
DCOM- 20150417
LR  - 20220318
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 14
DP  - 2014 Jun 30
TI  - Body mass index is not a reliable tool in predicting celiac disease in children.
PG  - 165
LID - 10.1186/1471-2431-14-165 [doi]
AB  - BACKGROUND: Untreated celiac disease is traditionally believed to be associated 
      with malabsorption and underweight. However, studies describing body mass index 
      (BMI) in individuals at the time of diagnosis have shown contradictory results. 
      We investigated the differences in weight, height, and BMI in 12- year-old 
      children with screening-detected celiac disease compared to their healthy peers. 
      METHODS: In a population-based screening study of 12,632 12-year-old children, 
      blood samples were analyzed for markers of celiac disease. Children with elevated 
      markers were referred for a small bowel biopsy. Weight and height were measured 
      in 239 out of 242 children with screening-detected celiac disease (57.3% girls) 
      and in 12,227 children without celiac disease (48.5% girls). BMI was categorized 
      according to the International Obesity Task Force. Age- and sex-specific cut-off 
      points for underweight, normal weight, and overweight were used. RESULTS: 
      Children with celiac disease weighed less and were shorter than their peers 
      (median weight 45.2 kg, interquartile range (IQR) 40.2-52.2 kg vs. 47.0 kg, IQR 
      41.1-54.4 kg, respectively, p = 0.01; median height 156.5 cm, IQR 151.0-162.0 cm 
      vs. 157.5 cm, IQR 152.0-163.0 cm, respectively, p = 0.04). In comparing those 
      with celiac disease to their healthy peers, 4.2% vs. 5.2% were underweight, 82.0% 
      vs. 72.8% were normal weight, and 13.8% vs. 21.9% were overweight, respectively. 
      There was no association between being underweight and the risk of having 
      undiagnosed celiac disease (Odds ratio (OR) 1.3, 95% CI 0.7-2.4), but the risk 
      was significantly lower among overweight children (OR 0.56, 95% CI 0.4-0.8). 
      Median BMI was slightly lower among the children with screening-detected celiac 
      disease compared to their healthy peers (18.6 kg/m2, IQR 17.1-19.8 kg/m2 vs. 18.8 
      kg/m2, IQR 17.2-21.1 kg/m2, respectively, p = 0.05), but most of the celiac 
      disease cases had a normal BMI. CONCLUSIONS: At a population level, children with 
      celiac disease weigh less, are shorter, and have a lower BMI compared to their 
      peers without celiac disease, and this emphasizes the importance of early 
      recognition and treatment of the condition. However, at an individual level, 
      growth parameters are not reliable in establishing the diagnosis.
FAU - van der Pals, Maria
AU  - van der Pals M
AD  - Department of Pediatrics, Clinical Sciences, Skane University Hospital, Malmo, 
      Lund University, SE-205 02 Lund, Sweden. maria.vanderpals@med.lu.se.
FAU - Myleus, Anna
AU  - Myleus A
FAU - Norstrom, Fredrik
AU  - Norstrom F
FAU - Hammarroth, Solveig
AU  - Hammarroth S
FAU - Hogberg, Lotta
AU  - Hogberg L
FAU - Rosen, Anna
AU  - Rosen A
FAU - Ivarsson, Anneli
AU  - Ivarsson A
FAU - Carlsson, Annelie
AU  - Carlsson A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140630
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Autoantibodies/blood
MH  - Biomarkers/blood
MH  - Body Height
MH  - *Body Mass Index
MH  - Body Weight
MH  - Case-Control Studies
MH  - Celiac Disease/blood/*diagnosis
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Mass Screening
MH  - Sweden
PMC - PMC4094403
EDAT- 2014/07/02 06:00
MHDA- 2015/04/18 06:00
PMCR- 2014/06/30
CRDT- 2014/07/02 06:00
PHST- 2014/03/06 00:00 [received]
PHST- 2014/06/12 00:00 [accepted]
PHST- 2014/07/02 06:00 [entrez]
PHST- 2014/07/02 06:00 [pubmed]
PHST- 2015/04/18 06:00 [medline]
PHST- 2014/06/30 00:00 [pmc-release]
AID - 1471-2431-14-165 [pii]
AID - 10.1186/1471-2431-14-165 [doi]
PST - epublish
SO  - BMC Pediatr. 2014 Jun 30;14:165. doi: 10.1186/1471-2431-14-165.