PMID- 24982374
OWN - NLM
STAT- MEDLINE
DCOM- 20140821
LR  - 20181202
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 34
IP  - 7
DP  - 2014 Jul
TI  - Perioperative venous thromboembolism in patients with gynecological malignancies: 
      a lesson from four years of recent clinical experience.
PG  - 3589-95
AB  - AIM: To analyze clinical characteristics of venous thromboembolisms (VTE) in 
      gynecological malignancies, and to find a cost-effective prophylaxis procedure 
      for post-operative VTE. PATIENTS AND METHODS: We analyzed clinical 
      characteristics of 751 patients who underwent definitive surgery for gynecologic 
      malignancies, and cost-effectiveness of VTE prophylaxis. RESULTS: VTE was 
      diagnosed preoperatively in 4.5% of ovarian cancer cases, more frequently than 
      any other type (p<0.005). Older age and greater length of operation were 
      independent risk factors for postoperative VTE. To prevent eight VTEs in 738 
      malignant cases, which occurred during day 2 to 10, $617,783, $726,185, or 
      $994,222 were necessary for continuous VTE prophylaxis, using either 
      unfractionated heparin (UFH), low-molecular weight heparin or fondaparinux, 
      respectively. CONCLUSION: A strategy which might be cost-effective for 
      post-surgical management of gynecological malignances is use of UFH three times 
      combined with graduated compression stockings and intermittent pneumatic 
      compression, thorough SpO2 monitoring, and perioperative measurements of the 
      circumference of both sides of thighs and calves.
CI  - Copyright(c) 2014 International Institute of Anticancer Research (Dr. John G. 
      Delinassios), All rights reserved.
FAU - Morimoto, Akiko
AU  - Morimoto A
AD  - Department of Obstetrics and Gynecology, Osaka University Graduate School of 
      Medicine, Yamadaoka, Suita, Osaka, Japan.
FAU - Ueda, Yutaka
AU  - Ueda Y
AD  - Department of Obstetrics and Gynecology, Osaka University Graduate School of 
      Medicine, Yamadaoka, Suita, Osaka, Japan ZVF03563@nifty.ne.jp.
FAU - Yokoi, Takeshi
AU  - Yokoi T
AD  - Department of Obstetrics and Gynecology, Kaizuka City Hospital, Kaizuka, Osaka, 
      Japan.
FAU - Tokizawa, Yuki
AU  - Tokizawa Y
AD  - Department of Obstetrics and Gynecology, Osaka University Graduate School of 
      Medicine, Yamadaoka, Suita, Osaka, Japan.
FAU - Yoshino, Kiyoshi
AU  - Yoshino K
AD  - Department of Obstetrics and Gynecology, Osaka University Graduate School of 
      Medicine, Yamadaoka, Suita, Osaka, Japan.
FAU - Fujita, Masami
AU  - Fujita M
AD  - Department of Obstetrics and Gynecology, Osaka University Graduate School of 
      Medicine, Yamadaoka, Suita, Osaka, Japan.
FAU - Kimura, Toshihiro
AU  - Kimura T
AD  - Department of Obstetrics and Gynecology, Osaka University Graduate School of 
      Medicine, Yamadaoka, Suita, Osaka, Japan.
FAU - Kobayashi, Eiji
AU  - Kobayashi E
AD  - Department of Obstetrics and Gynecology, Osaka University Graduate School of 
      Medicine, Yamadaoka, Suita, Osaka, Japan.
FAU - Matsuzaki, Shinya
AU  - Matsuzaki S
AD  - Department of Obstetrics and Gynecology, Osaka University Graduate School of 
      Medicine, Yamadaoka, Suita, Osaka, Japan.
FAU - Egawa-Takata, Tomomi
AU  - Egawa-Takata T
AD  - Department of Obstetrics and Gynecology, Osaka University Graduate School of 
      Medicine, Yamadaoka, Suita, Osaka, Japan.
FAU - Sawada, Kenjiro
AU  - Sawada K
AD  - Department of Obstetrics and Gynecology, Osaka University Graduate School of 
      Medicine, Yamadaoka, Suita, Osaka, Japan.
FAU - Tsutsui, Tateki
AU  - Tsutsui T
AD  - Department of Obstetrics and Gynecology, Osaka University Graduate School of 
      Medicine, Yamadaoka, Suita, Osaka, Japan.
FAU - Kimura, Tadashi
AU  - Kimura T
AD  - Department of Obstetrics and Gynecology, Osaka University Graduate School of 
      Medicine, Yamadaoka, Suita, Osaka, Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Polysaccharides)
RN  - 9005-49-6 (Heparin)
RN  - J177FOW5JL (Fondaparinux)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticoagulants/*administration & dosage/economics
MH  - Cost-Benefit Analysis
MH  - Female
MH  - Fondaparinux
MH  - Genital Neoplasms, Female/blood/economics/*surgery
MH  - Heparin/*administration & dosage/economics
MH  - Heparin, Low-Molecular-Weight/administration & dosage/economics
MH  - Humans
MH  - Japan
MH  - Middle Aged
MH  - Perioperative Period
MH  - Polysaccharides/administration & dosage/economics
MH  - Venous Thromboembolism/economics/*prevention & control
OTO - NOTNLM
OT  - Economic comparison
OT  - UFH
OT  - VTE
OT  - fondaparinux
OT  - gynecological malignancy
OT  - post-operative
OT  - prophylaxis
OT  - short duration
EDAT- 2014/07/02 06:00
MHDA- 2014/08/22 06:00
CRDT- 2014/07/02 06:00
PHST- 2014/07/02 06:00 [entrez]
PHST- 2014/07/02 06:00 [pubmed]
PHST- 2014/08/22 06:00 [medline]
AID - 34/7/3589 [pii]
PST - ppublish
SO  - Anticancer Res. 2014 Jul;34(7):3589-95.