PMID- 24982550
OWN - NLM
STAT- MEDLINE
DCOM- 20150306
LR  - 20211021
IS  - 1928-9022 (Electronic)
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 78
IP  - 3
DP  - 2014 Jul
TI  - Effect of oral administration of unfractionated heparin (UFH) on coagulation 
      parameters in plasma and levels of urine and fecal heparin in dogs.
PG  - 193-201
AB  - The effects of heparin administration, by the oral route, were evaluated in dogs. 
      In single and multiple dose studies (single 7.5 mg/kg, multiple 3 x 7.5 mg/kg per 
      48 h), plasma, urine, and fecal samples were collected at various times up to 120 
      h after oral administration of unfractionated heparin. Changes in plasma and 
      urine anti-Xa activity, plasma and urine anti-IIa activity, plasma activated 
      partial thromboplastin time (APTT) and antithrombin (ATIII), and chemical heparin 
      in urine and feces were examined with time. There was support for heparin 
      absorption, with significant differences in APTT, heparin in plasma as determined 
      by anti-Xa activity (Heptest) in the single dose study and plasma anti-Xa 
      activity, anti-IIa activity and ATIII; and chemical heparin in urine in the 
      multiple dose study. No clinical evidence of bleeding was detected in any dog 
      during the studies. Oral heparin therapy may be applicable for thromboembolic 
      disease in animals. Further studies are warranted to determine the effects of 
      oral heparin at the endothelial level in the dog.
FAU - Erickson, Malathi
AU  - Erickson M
AD  - Department of Small Animal Clinical Sciences (Erickson, Carr, Stickney) and 
      Department of Veterinary Biomedical Sciences (Hiebert), Western College of 
      Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4.
FAU - Hiebert, Linda M
AU  - Hiebert LM
AD  - Department of Small Animal Clinical Sciences (Erickson, Carr, Stickney) and 
      Department of Veterinary Biomedical Sciences (Hiebert), Western College of 
      Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4.
FAU - Carr, Anthony P
AU  - Carr AP
AD  - Department of Small Animal Clinical Sciences (Erickson, Carr, Stickney) and 
      Department of Veterinary Biomedical Sciences (Hiebert), Western College of 
      Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4.
FAU - Stickney, Jocelyn D
AU  - Stickney JD
AD  - Department of Small Animal Clinical Sciences (Erickson, Carr, Stickney) and 
      Department of Veterinary Biomedical Sciences (Hiebert), Western College of 
      Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
RN  - 0 (Anticoagulants)
RN  - 0 (Antithrombins)
RN  - 9001-26-7 (Prothrombin)
RN  - 9002-04-4 (Factor IIa)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.22 (Factor IXa)
RN  - EC 3.4.21.6 (Factor Xa)
SB  - IM
MH  - Animals
MH  - Anticoagulants/blood/chemistry/pharmacokinetics/pharmacology/urine
MH  - Antithrombins/metabolism
MH  - Dogs/*blood/*metabolism/urine
MH  - Factor IXa/metabolism
MH  - Factor Xa/metabolism
MH  - Feces/*chemistry
MH  - Female
MH  - Heparin/*blood/chemistry/pharmacokinetics/*pharmacology/urine
MH  - Male
MH  - Prothrombin/metabolism
PMC - PMC4068410
EDAT- 2014/07/02 06:00
MHDA- 2015/03/07 06:00
PMCR- 2015/01/01
CRDT- 2014/07/02 06:00
PHST- 2013/04/13 00:00 [received]
PHST- 2013/07/03 00:00 [accepted]
PHST- 2014/07/02 06:00 [entrez]
PHST- 2014/07/02 06:00 [pubmed]
PHST- 2015/03/07 06:00 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - cjvr_07_193 [pii]
PST - ppublish
SO  - Can J Vet Res. 2014 Jul;78(3):193-201.