PMID- 24982551
OWN - NLM
STAT- MEDLINE
DCOM- 20150306
LR  - 20211021
IS  - 1928-9022 (Electronic)
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 78
IP  - 3
DP  - 2014 Jul
TI  - The interaction of nitrous oxide and fentanyl on the minimum alveolar 
      concentration of sevoflurane blocking motor movement (MACNM) in dogs.
PG  - 202-6
AB  - The study objective was to determine the effects of 70% nitrous oxide (N2O) and 
      fentanyl on the end-tidal concentration of sevoflurane necessary to prevent 
      movement (MACNM) in response to noxious stimulation in dogs. Six healthy, adult, 
      intact male, mixed-breed dogs were used on 3 occasions in a randomized crossover 
      design. After induction of anesthesia with sevoflurane, each of the following 
      treatments was randomly administered: fentanyl loading dose (Ld) of 15 mug/kg and 
      infusion of 6 mug/kg per hour [treatment 1 (T1)], 70% N2O (T2), or fentanyl (Ld of 
      15 mug/kg and infusion of 6 mug/kg per hour) combined with 70% N2O (T3). Each dog 
      received each of the 3 treatments once during the 3-week period. Determination of 
      MACNM was initiated 90 min after the start of each treatment. The values were 
      compared using the baseline MACNM, which had been determined in a previous study 
      on the same group of dogs. Data were analyzed using a mixed-model analysis of 
      variance (ANOVA) and Tukey-Kramer tests, and expressed as least squares mean +/- 
      SEM. The baseline MACNM decreased by 36.6 +/- 4.0%, 15.0 +/- 4.0%, and 46.0 +/- 4.0% 
      for T1, T2, and T3, respectively (P < 0.05), and differed (P < 0.05) among 
      treatments. Mean fentanyl plasma concentrations did not differ (P >/= 0.05) between 
      T1 (3.70 +/- 0.56 ng/mL) and T3 (3.50 +/- 0.56 ng/mL). The combination of fentanyl 
      and N2O resulted in a greater sevoflurane MACNM sparing effect than either 
      treatment alone.
FAU - Seddighi, Reza
AU  - Seddighi R
AD  - Department of Large Animal Clinical Sciences (Seddighi, Doherty); Department of 
      Small Animal Clinical Sciences (Egger, Henn); Department of Biomedical and 
      Diagnostic Sciences (Rohrbach), College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Tennessee, USA; Department of Anatomy & Physiology, College 
      of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA 
      (Kukanich).
FAU - Doherty, Thomas J
AU  - Doherty TJ
AD  - Department of Large Animal Clinical Sciences (Seddighi, Doherty); Department of 
      Small Animal Clinical Sciences (Egger, Henn); Department of Biomedical and 
      Diagnostic Sciences (Rohrbach), College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Tennessee, USA; Department of Anatomy & Physiology, College 
      of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA 
      (Kukanich).
FAU - Kukanich, Butch
AU  - Kukanich B
AD  - Department of Large Animal Clinical Sciences (Seddighi, Doherty); Department of 
      Small Animal Clinical Sciences (Egger, Henn); Department of Biomedical and 
      Diagnostic Sciences (Rohrbach), College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Tennessee, USA; Department of Anatomy & Physiology, College 
      of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA 
      (Kukanich).
FAU - Egger, Christine M
AU  - Egger CM
AD  - Department of Large Animal Clinical Sciences (Seddighi, Doherty); Department of 
      Small Animal Clinical Sciences (Egger, Henn); Department of Biomedical and 
      Diagnostic Sciences (Rohrbach), College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Tennessee, USA; Department of Anatomy & Physiology, College 
      of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA 
      (Kukanich).
FAU - Henn, Melissa A
AU  - Henn MA
AD  - Department of Large Animal Clinical Sciences (Seddighi, Doherty); Department of 
      Small Animal Clinical Sciences (Egger, Henn); Department of Biomedical and 
      Diagnostic Sciences (Rohrbach), College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Tennessee, USA; Department of Anatomy & Physiology, College 
      of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA 
      (Kukanich).
FAU - Long, Whitney M
AU  - Long WM
AD  - Department of Large Animal Clinical Sciences (Seddighi, Doherty); Department of 
      Small Animal Clinical Sciences (Egger, Henn); Department of Biomedical and 
      Diagnostic Sciences (Rohrbach), College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Tennessee, USA; Department of Anatomy & Physiology, College 
      of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA 
      (Kukanich).
FAU - Rohrbach, Barton W
AU  - Rohrbach BW
AD  - Department of Large Animal Clinical Sciences (Seddighi, Doherty); Department of 
      Small Animal Clinical Sciences (Egger, Henn); Department of Biomedical and 
      Diagnostic Sciences (Rohrbach), College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Tennessee, USA; Department of Anatomy & Physiology, College 
      of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA 
      (Kukanich).
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - K50XQU1029 (Nitrous Oxide)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Anesthetics, Inhalation/administration & dosage/pharmacokinetics/pharmacology
MH  - Anesthetics, Intravenous/administration & dosage/pharmacokinetics/pharmacology
MH  - Animals
MH  - Cross-Over Studies
MH  - *Dogs
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Drug Therapy, Combination
MH  - Fentanyl/administration & dosage/*pharmacokinetics/*pharmacology
MH  - Male
MH  - Methyl Ethers/administration & dosage/*pharmacology
MH  - Motor Activity/drug effects
MH  - Nitrous Oxide/administration & dosage/*pharmacokinetics/*pharmacology
MH  - Sevoflurane
PMC - PMC4068411
EDAT- 2014/07/02 06:00
MHDA- 2015/03/07 06:00
PMCR- 2015/01/01
CRDT- 2014/07/02 06:00
PHST- 2013/02/18 00:00 [received]
PHST- 2013/07/22 00:00 [accepted]
PHST- 2014/07/02 06:00 [entrez]
PHST- 2014/07/02 06:00 [pubmed]
PHST- 2015/03/07 06:00 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - cjvr_07_202 [pii]
PST - ppublish
SO  - Can J Vet Res. 2014 Jul;78(3):202-6.