PMID- 24984051
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20141111
IS  - 1365-2060 (Electronic)
IS  - 0785-3890 (Linking)
VI  - 46
IP  - 7
DP  - 2014 Nov
TI  - Immunoglobulin E (IgE) and ischemic heart disease. Which came first, the chicken 
      or the egg?
PG  - 456-63
LID - 10.3109/07853890.2014.927714 [doi]
AB  - Several lines of evidence demonstrate that the immune system plays a pivotal role 
      in development and progression of ischemic heart disease (IHD). More recently, a 
      series of biological and clinical investigations has generated new interest about 
      the existence of a relationship between a specific class of immunoglobulin, that 
      is immunoglobulin E (IgE), and IHD. Data obtained in several epidemiological 
      studies have convincingly demonstrated that the concentration of total serum IgEs 
      is significantly increased in patients with IHD and often correlates with the 
      prognosis. The putative mechanisms are essentially mediated by a physiological 
      interaction between IgEs and mast cells, which triggers the direct or indirect 
      release of a variety of substances that are actively involved in the pathogenesis 
      of myocardial ischemia and thrombosis. Regardless of these important evidences, a 
      causality dilemma remains, since it is still unclear whether increased IgE levels 
      are a consequence of IHD or, rather, IHD is an underlying cause of increased IgE 
      levels. The answer would allow us to recognize whether total IgEs may be 
      considered simple biomarkers or risk factors of IHD, thus paving the way to 
      investigations focused on immunotherapy or avoidance of allergenic foods for 
      reducing serum IgEs in patients at risk of IHD.
FAU - Lippi, Giuseppe
AU  - Lippi G
AD  - Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma , 
      Parma , Italy.
FAU - Cervellin, Gianfranco
AU  - Cervellin G
FAU - Sanchis-Gomar, Fabian
AU  - Sanchis-Gomar F
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140701
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Coronary Vessel Anomalies/etiology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Job Syndrome/complications
MH  - Mast Cells/*metabolism
MH  - Myocardial Ischemia/*epidemiology/*immunology
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - IgE
OT  - immune system
OT  - immunoglobulin E
OT  - ischemic heart disease
EDAT- 2014/07/02 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/07/02 06:00
PHST- 2014/07/02 06:00 [entrez]
PHST- 2014/07/02 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.3109/07853890.2014.927714 [doi]
PST - ppublish
SO  - Ann Med. 2014 Nov;46(7):456-63. doi: 10.3109/07853890.2014.927714. Epub 2014 Jul 
      1.