PMID- 24984148
OWN - NLM
STAT- MEDLINE
DCOM- 20150414
LR  - 20200106
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 37
DP  - 2014 Oct
TI  - Serum Brain-derived neurotrophic factor levels in Chinese children with autism 
      spectrum disorders: a pilot study.
PG  - 65-8
LID - S0736-5748(14)00095-1 [pii]
LID - 10.1016/j.ijdevneu.2014.06.013 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) plays a critical role in the 
      pathogenesis of Autism spectrum disorders (ASD). The purpose of this study was to 
      investigate the potential role of BDNF in Chinese children with ASD. Sixty 
      patients (48 male, 12 female) diagnosed with ASD and 60 healthy sex and age 
      control subjects were assessed for serum BDNF content at admission. BDNF were 
      assayed with enzyme-linked immunosorbent assay methods, and severity of ASD was 
      evaluated with the Childhood Autism Rating Scale (CARS) Score. The results 
      indicated that the median serum BDNF levels were significantly (P<0.0001) higher 
      in children with ASD as compared to normal cases [17.6(IQR: 13.7-21.4) ng/ml and 
      11.5(9.6-13.8) ng/ml, respectively]. Based on the receiver operating 
      characteristic (ROC) curve, the optimal cut-off value of serum BDNF levels as an 
      indicator for auxiliary diagnosis of autism was projected to be 15.0 ng/ml. 
      Further, we found that an increased risk of ASD was associated with BDNF levels 
      >15.0 ng/ml (adjusted OR 10.4, 95% CI: 4.39-29.32) after adjusting for above 
      possible confounders. Our study demonstrated that serum BDNF levels were 
      associated with ASD, and higher levels could be considered as an independent risk 
      factor of ASD.
CI  - Copyright (c) 2014 ISDN. Published by Elsevier Ltd. All rights reserved.
FAU - Zhang, Qing-biao
AU  - Zhang QB
AD  - Department of Pediatric Internal Medicine II, Linyi People's Hospital, Linyi, 
      Shandong Province, PR China.
FAU - Jiang, Liang-fu
AU  - Jiang LF
AD  - Department of Pediatric Surgery I, Linyi People's Hospital, Linyi, Shandong 
      Province, PR China.
FAU - Kong, Ling-yu
AU  - Kong LY
AD  - Department of Breast Surgery, Linyi Tumor's Hospital, Linyi, Shandong Province, 
      PR China.
FAU - Lu, Yuan-Jun
AU  - Lu YJ
AD  - Department of Pediatric Surgery I, Linyi People's Hospital, Linyi, Shandong 
      Province, PR China. Electronic address: YCHAO157@163.com.
LA  - eng
PT  - Journal Article
DEP - 20140628
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (brain-derived growth factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child Development Disorders, Pervasive/*blood
MH  - Child, Preschool
MH  - China
MH  - Female
MH  - Humans
MH  - Male
MH  - Pilot Projects
MH  - ROC Curve
MH  - Severity of Illness Index
MH  - Statistics as Topic
OTO - NOTNLM
OT  - Autism spectrum disorders
OT  - Brain-derived neurotrophic factor
OT  - Chinese
OT  - Risk
EDAT- 2014/07/02 06:00
MHDA- 2015/04/15 06:00
CRDT- 2014/07/02 06:00
PHST- 2014/05/26 00:00 [received]
PHST- 2014/06/20 00:00 [revised]
PHST- 2014/06/20 00:00 [accepted]
PHST- 2014/07/02 06:00 [entrez]
PHST- 2014/07/02 06:00 [pubmed]
PHST- 2015/04/15 06:00 [medline]
AID - S0736-5748(14)00095-1 [pii]
AID - 10.1016/j.ijdevneu.2014.06.013 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2014 Oct;37:65-8. doi: 10.1016/j.ijdevneu.2014.06.013. Epub 
      2014 Jun 28.