PMID- 24984460
OWN - NLM
STAT- MEDLINE
DCOM- 20150901
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 32
IP  - 3
DP  - 2014 Mar
TI  - [Simultaneous determination of four Sudan dyes in blood by solid-phase extraction 
      combined with ultra-fast liquid chromatography-tandem mass spectrometry].
PG  - 224-9
AB  - A method for the simultaneous determination of Sudan I, II, III, and IV in blood 
      samples by solid-phase extraction (SPE) combined with ultra-fast liquid 
      chromatography-tandem mass spectrometry (UFLC-MS/MS) has been established. The 
      samples were extracted with acetonitrile by vortex and vibrate technique, and 
      then the supernatant was diluted with equal volume of water and cleaned up by a 
      C18 SPE column. The separation was performed on an Agilent Eclipse Plus C18 
      column (100 mm x 2.1 mm, 1.8 microm) by gradient elution with acetonitrile 
      containing 0.1% (v/v) formic acid and 0.1% (v/v) formic acid aqueous solution as 
      the mobile phases. The electrospray ionization (ESI) source in the positive mode 
      and multiple reaction monitoring (MRM) mode were used for the quantitative 
      analysis. In addition, the phenomenon of E-Z optical isomer occurred by the azo 
      group from Sudan III and IV was found, and the influencing factors were 
      discussed. The results showed that the calibration curves were in good linearity 
      for the four Sudan dyes ranged from 0.1 to 20.0 microg/L with the correlation 
      coefficients of more than 0.999. The average recoveries were from 93.0% to 108.2% 
      with the relative standard deviations (RSDs) from 4.8% to 9.5%. The limits of 
      detection (LODs) and the limits of quantification (LOQs) were 0.06 microg/L and 
      0.2 microg/L for the four analytes, respectively. The developed method is simple, 
      rapid, and highly sensitive. It can be used for the determination of trace Sudan 
      dyes in blood samples.
FAU - Zhu, Hao
AU  - Zhu H
FAU - Huang, Kunyu
AU  - Huang K
FAU - Fu, Jianfei
AU  - Fu J
FAU - Hu, Yue
AU  - Hu Y
FAU - Huang, Xianni
AU  - Huang X
FAU - Chen, Xiaohong
AU  - Chen X
FAU - Zou, Baobo
AU  - Zou B
FAU - Jin, Micong
AU  - Jin M
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Azo Compounds)
RN  - 0 (Coloring Agents)
RN  - 0 (Naphthols)
RN  - 48I7IBB68J (1-phenylazo-2-naphthol)
RN  - 8C1M5O3ECT (sudan red)
RN  - I35E9QU96C (Scarlet Red)
RN  - ND733RX3JN (sudan III)
SB  - IM
MH  - Azo Compounds
MH  - Blood Chemical Analysis/*methods
MH  - *Chromatography, Liquid
MH  - Coloring Agents/*analysis
MH  - Limit of Detection
MH  - Naphthols
MH  - Solid Phase Extraction
MH  - *Tandem Mass Spectrometry
EDAT- 2014/07/06 06:00
MHDA- 2015/09/02 06:00
CRDT- 2014/07/03 06:00
PHST- 2014/07/03 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/09/02 06:00 [medline]
AID - 10.3724/sp.j.1123.2013.11005 [doi]
PST - ppublish
SO  - Se Pu. 2014 Mar;32(3):224-9. doi: 10.3724/sp.j.1123.2013.11005.