PMID- 24984898
OWN - NLM
STAT- MEDLINE
DCOM- 20141031
LR  - 20211021
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 34
IP  - 9
DP  - 2014 Sep
TI  - Caloric restriction impedes age-related decline of mitochondrial function and 
      neuronal activity.
PG  - 1440-3
LID - 10.1038/jcbfm.2014.114 [doi]
AB  - Caloric restriction (CR) prolongs lifespan and retards many detrimental effects 
      of aging, but its effect on brain mitochondrial function and neuronal 
      activity--especially in healthy aging--remains unexplored. Here we measured rates 
      of neuronal glucose oxidation and glutamate-glutamine neurotransmitter cycling in 
      young control, old control (i.e., healthy aging), and old CR rats using in vivo 
      nuclear magnetic resonance spectroscopy. We found that, compared with the young 
      control, neuronal energy production and neurotransmission rates were 
      significantly reduced in healthy aging, but were preserved in old CR rats. The 
      results suggest that CR mitigated the age-related deceleration of brain 
      physiology.
FAU - Lin, Ai-Ling
AU  - Lin AL
AD  - 1] Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, 
      USA [2] Department of Pharmacology and Nutritional Sciences, University of 
      Kentucky, Lexington, Kentucky, USA.
FAU - Coman, Daniel
AU  - Coman D
AD  - 1] Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, 
      USA [2] Quantitative Neuroscience with Magnetic Resonance Core Center, Yale 
      University, New Haven, Connecticut, USA [3] Department of Diagnostic Radiology, 
      Yale University, New Haven, Connecticut, USA.
FAU - Jiang, Lihong
AU  - Jiang L
AD  - 1] Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, 
      USA [2] Quantitative Neuroscience with Magnetic Resonance Core Center, Yale 
      University, New Haven, Connecticut, USA [3] Department of Diagnostic Radiology, 
      Yale University, New Haven, Connecticut, USA.
FAU - Rothman, Douglas L
AU  - Rothman DL
AD  - 1] Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, 
      USA [2] Quantitative Neuroscience with Magnetic Resonance Core Center, Yale 
      University, New Haven, Connecticut, USA [3] Department of Diagnostic Radiology, 
      Yale University, New Haven, Connecticut, USA [4] Department of Biomedical 
      Engineering, Yale University, New Haven, Connecticut, USA.
FAU - Hyder, Fahmeed
AU  - Hyder F
AD  - 1] Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, 
      USA [2] Quantitative Neuroscience with Magnetic Resonance Core Center, Yale 
      University, New Haven, Connecticut, USA [3] Department of Diagnostic Radiology, 
      Yale University, New Haven, Connecticut, USA [4] Department of Biomedical 
      Engineering, Yale University, New Haven, Connecticut, USA.
LA  - eng
GR  - R01 AG 034953/AG/NIA NIH HHS/United States
GR  - P30 NS052519/NS/NINDS NIH HHS/United States
GR  - R01 MH067528/MH/NIMH NIH HHS/United States
GR  - KL2 TR001118/TR/NCATS NIH HHS/United States
GR  - R01 AG034953/AG/NIA NIH HHS/United States
GR  - UL1 TR000142/TR/NCATS NIH HHS/United States
GR  - R01 MH-067528/MH/NIMH NIH HHS/United States
GR  - P30 NS-052519/NS/NINDS NIH HHS/United States
GR  - UL1 TR001120/TR/NCATS NIH HHS/United States
GR  - K01AG040164/AG/NIA NIH HHS/United States
GR  - K01 AG040164/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140702
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0RH81L854J (Glutamine)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - Glutamic Acid/*metabolism
MH  - Glutamine/*metabolism
MH  - Male
MH  - Mitochondria/*metabolism
MH  - Rats
MH  - Rats, Inbred F344
MH  - Synaptic Transmission/*physiology
PMC - PMC4158670
EDAT- 2014/07/06 06:00
MHDA- 2014/11/02 06:00
PMCR- 2015/09/01
CRDT- 2014/07/03 06:00
PHST- 2014/02/13 00:00 [received]
PHST- 2014/05/08 00:00 [revised]
PHST- 2014/06/05 00:00 [accepted]
PHST- 2014/07/03 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2014/11/02 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - jcbfm2014114 [pii]
AID - 10.1038/jcbfm.2014.114 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2014 Sep;34(9):1440-3. doi: 10.1038/jcbfm.2014.114. 
      Epub 2014 Jul 2.