PMID- 24985009
OWN - NLM
STAT- MEDLINE
DCOM- 20150209
LR  - 20221207
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 30
IP  - 7-8
DP  - 2014 Jul-Aug
TI  - Genetic variants in desaturase gene, erythrocyte fatty acids, and risk for type 2 
      diabetes in Chinese Hans.
PG  - 897-902
LID - S0899-9007(14)00047-1 [pii]
LID - 10.1016/j.nut.2014.01.006 [doi]
AB  - OBJECTIVE: The aim of this study was to examine the association of the genetic 
      variants in the fatty acid desaturase (FADS) gene cluster with erythrocyte 
      phospholipid fatty acids (PLFA), and their relation to risk for type 2 diabetes 
      mellitus (T2DM) in Han Chinese. METHODS: Seven hundred and fifty-eight patients 
      with T2DM and 400 healthy individuals were recruited. The erythrocyte PLFA and 
      single-nucleotide polymorphism were determined by standard method. RESULTS: Minor 
      allele homozygotes and heterozygotes of rs174575 and rs174537 had lower PL 20:4 
      omega-6 levels in healthy individuals. Minor allele homozygotes and heterozygotes of 
      rs174455 in FADS3 gene had lower levels of 22:5 omega-3, 20:4 omega-6, and Delta5desaturase 
      activity in patients with T2DM. Erythrocyte membrane PL 18:3 omega-3 (P for trend = 
      0.002), 22:5 omega-3 (P for trend < 0.001), omega-3 polyunsaturated fatty acid (P for 
      trend < 0.001), and omega-3:omega-6 (P for trend < 0.001) were significantly inversely 
      associated with risk for T2DM. CONCLUSION: Genetic variants in the FADS gene 
      cluster are associated with altered erythrocyte PLFAs. High levels of PL 18:3 
      omega-3, 22:5 omega-3, and total omega-3 polyunsaturated fatty acid were associated with low 
      risk for T2DM.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Huang, Tao
AU  - Huang T
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China; 
      Department of International Health, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, MD, USA.
FAU - Sun, Jianqin
AU  - Sun J
AD  - Clinical Nutrition Center, Huadong Hospital, Fudan University, Shanghai, China.
FAU - Chen, Yanqiu
AU  - Chen Y
AD  - Clinical Nutrition Center, Huadong Hospital, Fudan University, Shanghai, China.
FAU - Xie, Hua
AU  - Xie H
AD  - Clinical Nutrition Center, Huadong Hospital, Fudan University, Shanghai, China.
FAU - Xu, Danfeng
AU  - Xu D
AD  - Clinical Nutrition Center, Huadong Hospital, Fudan University, Shanghai, China.
FAU - Huang, Jinyan
AU  - Huang J
AD  - Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.
FAU - Li, Duo
AU  - Li D
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. 
      Electronic address: duoli@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140130
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Delta-5 Fatty Acid Desaturase)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Omega-6)
RN  - 0 (Phospholipids)
RN  - EC 1.14.19.- (Fatty Acid Desaturases)
RN  - EC 1.14.19.3 (FADS2 protein, human)
RN  - EC 1.14.19.3 (FADS3 protein, human)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Asian People/*genetics
MH  - China
MH  - Delta-5 Fatty Acid Desaturase
MH  - Diabetes Mellitus, Type 2/blood/*genetics
MH  - Erythrocytes/metabolism
MH  - Ethnicity/genetics
MH  - Fatty Acid Desaturases/*genetics/metabolism
MH  - Fatty Acids, Omega-3/*blood
MH  - Fatty Acids, Omega-6/blood
MH  - Female
MH  - *Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phospholipids/*blood
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
OTO - NOTNLM
OT  - Fatty acid desaturase
OT  - Phospholipids
OT  - Single-nucleotide polymorphism
OT  - Type 2 diabetes
EDAT- 2014/07/06 06:00
MHDA- 2015/02/11 06:00
CRDT- 2014/07/03 06:00
PHST- 2013/05/19 00:00 [received]
PHST- 2013/12/12 00:00 [revised]
PHST- 2014/01/21 00:00 [accepted]
PHST- 2014/07/03 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/02/11 06:00 [medline]
AID - S0899-9007(14)00047-1 [pii]
AID - 10.1016/j.nut.2014.01.006 [doi]
PST - ppublish
SO  - Nutrition. 2014 Jul-Aug;30(7-8):897-902. doi: 10.1016/j.nut.2014.01.006. Epub 
      2014 Jan 30.