PMID- 24985181
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20140702
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 35
IP  - 6
DP  - 2014 Jun
TI  - [Application of three-probe fluorescence in situ hybridization panel in the 
      diagnosis of pediatric B cell acute lymphoblastic leukemia].
PG  - 542-5
LID - 10.3760/cma.j.issn.0253-2727.2014.06.015 [doi]
AB  - OBJECTIVE: To evaluate the three-probe fluorescence in situ hybridization (FISH) 
      panel in the diagnosis of pediatric B cell acute lymphoblastic leukemia (B-ALL). 
      METHODS: Three-probe (TELAML1, BCR-ABL and MLL) FISH and conventional cytogenetic 
      analysis were performed in 207 children with B-ALL. RESULTS: In 207 B-ALL 
      children, the three-probe FISH panel assay showed that 151 cases carried genetic 
      aberrancies with a positive rate of 72.9%, including 44 cases with typical 
      positive signal patterns and 148 cases with atypical signal patterns (among them 
      41 cases have multiprobe abberancy). The conventional cytogenetic analysis 
      detected 53 cases chromosomal abnormality with a positive rate of 25.6%. 
      CONCLUSION: The detection rate of genetic abnormalities in newly- diagnosed 
      pediatric B-ALL could be significantly improved by using three-probe FISH panel 
      upon conventional cytogenetic analysis.
FAU - Fan, Jing
AU  - Fan J
AD  - Department of Pathology, Institute of Hematology and Blood Diseases Hospital, 
      Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 
      300020, China.
FAU - Li, Chengwen
AU  - Li C
AD  - Department of Pathology, Institute of Hematology and Blood Diseases Hospital, 
      Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 
      300020, China.
FAU - Zhao, Jiawei
AU  - Zhao J
AD  - Department of Pathology, Institute of Hematology and Blood Diseases Hospital, 
      Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 
      300020, China.
FAU - Gong, Jinying
AU  - Gong J
AD  - Department of Pathology, Institute of Hematology and Blood Diseases Hospital, 
      Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 
      300020, China.
FAU - Zheng, Yingchun
AU  - Zheng Y
AD  - Department of Pathology, Institute of Hematology and Blood Diseases Hospital, 
      Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 
      300020, China.
FAU - Ru, Kun
AU  - Ru K
AD  - Department of Pathology, Institute of Hematology and Blood Diseases Hospital, 
      Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 
      300020, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Infant
MH  - Karyotyping
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/genetics
EDAT- 2014/07/06 06:00
MHDA- 2015/01/06 06:00
CRDT- 2014/07/03 06:00
PHST- 2014/07/03 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
AID - 10.3760/cma.j.issn.0253-2727.2014.06.015 [doi]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2014 Jun;35(6):542-5. doi: 
      10.3760/cma.j.issn.0253-2727.2014.06.015.