PMID- 24985577
OWN - NLM
STAT- MEDLINE
DCOM- 20150407
LR  - 20140702
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 127
IP  - 13
DP  - 2014
TI  - Duodenal-jejunal bypass surgery on type 2 diabetic rats reduces the expression of 
      matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in 
      the thoracic aorta.
PG  - 2423-8
AB  - BACKGROUND: Bariatric surgery offers a productive resolution of type 2 diabetes 
      mellitus (T2DM). The development of T2DM vasculopathy is due to chronic 
      inflammation, which increases matrix metalloproteinase-9 (MMP-9) and tissue 
      inhibitor of matrix metalloproteinase-1 (TIMP-1) expression. This study sought to 
      examine MMP-9 and TIMP-1 expression in the thoracic aorta after duodenal-jejunal 
      bypass (DJB) surgery on a T2DM rat model induced by a high-fat diet and low dose 
      streptozotocin (STZ). METHODS: Twenty-one T2DM Wistar rats induced by high-fat 
      diet and low dose STZ were randomly divided into DJB and sham duodenal-jejunal 
      bypass (S-DJB) groups. Ten Wistar rats were fed a normal diet as a control. 
      Recovery of gastrointestinal function post-operation and resumption of a normal 
      diet completed the experiment. Body weight, blood glucose, blood lipid levels, 
      and MMP-9 and TIMP-1 expression levels in aortic endothelial cells were measured 
      throughout. RESULTS: DJB rats showed significant weight loss 2 weeks 
      post-operation compared with S-DJB rats. After surgery, DJB rats showed 
      significant improvement and steady glycemic control with improved insulin 
      sensitivity and glucose tolerance. They also exhibited improved lipid metabolism 
      with a decrease in fasting free fatty acids (FFAs) and triglycerides (all P < 
      0.05). Immunohistochemistry showed decreased MMP-9 and TIMP-1 expression 12 weeks 
      after surgery (P < 0.01). CONCLUSIONS: DJB surgery on an induced T2DM rat model 
      improves blood glucose levels and lipids, following a high-fat diet and low dose 
      STZ treatment. In addition, DJB decreased MMP-9 and TIMP-1 expression in vascular 
      endothelial cells, which may play an important role in delaying the development 
      of T2DM vascular disease.
FAU - Maimaitiyusufu, Wubulikasimu
AU  - Maimaitiyusufu W
AD  - Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 
      Shandong 250012, China.
FAU - Han, Haifeng
AU  - Han H
AD  - Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 
      Shandong 250012, China.
FAU - Yan, Zhibo
AU  - Yan Z
AD  - Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 
      Shandong 250012, China.
FAU - Zhang, Xiang
AU  - Zhang X
AD  - Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 
      Shandong 250012, China.
FAU - Liu, Shaozhuang
AU  - Liu S
AD  - Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 
      Shandong 250012, China.
FAU - Zhang, Guangyong
AU  - Zhang G
AD  - Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 
      Shandong 250012, China.
FAU - Kasimu, Aimaiti
AU  - Kasimu A
AD  - Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 
      Shandong 250012, China.
FAU - Hu, Sanyuan
AU  - Hu S
AD  - Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 
      Shandong 250012, China. Email: husanyuan1962@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/*metabolism
MH  - *Bariatric Surgery
MH  - Body Weight/physiology
MH  - Diabetes Mellitus, Type 2/*enzymology
MH  - Male
MH  - Matrix Metalloproteinase 1/*metabolism
MH  - Matrix Metalloproteinase 9/*metabolism
MH  - Rats
EDAT- 2014/07/06 06:00
MHDA- 2015/04/08 06:00
CRDT- 2014/07/03 06:00
PHST- 2014/07/03 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/04/08 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2014;127(13):2423-8.