PMID- 24985902
OWN - NLM
STAT- MEDLINE
DCOM- 20141007
LR  - 20140815
IS  - 1554-527X (Electronic)
IS  - 0736-0266 (Linking)
VI  - 32
IP  - 10
DP  - 2014 Oct
TI  - Temporary inductions of matrix metalloprotease-3 (MMP-3) expression and cell 
      apoptosis are associated with tendon degeneration or rupture after corticosteroid 
      injection.
PG  - 1297-304
LID - 10.1002/jor.22681 [doi]
AB  - Corticosteroid injections are widely used to treat enthesopathy and tendinitis, 
      but are also associated with possible side effects, such as tendon degeneration 
      or rupture. However, the mechanism of tendon degeneration or rupture after 
      corticosteroid injection remains controversial. The purpose of this study was to 
      reveal the mechanism of tendon degeneration or rupture after injection of 
      triamcinolone acetonide (TA) or prednisolone (PSL). Forty-two rats were divided 
      into 3 groups: A normal saline injection group (control group), a TA injection 
      group, and a PSL injection group; the normal saline or corticosteroid was 
      injected around the Achilles tendon. One or 3 weeks after injection, the tendons 
      were subjected to biomechanical testing and histological analysis. At 1 week, the 
      biomechanical strength was significantly lower in the corticosteroid groups. 
      Histological analysis, at 1-week post-injection, showed collagen attenuation, 
      increased expression of MMP-3 and apoptotic cells in the corticosteroid groups. 
      The histological changes and biomechanical weaknesses of the tendon were not seen 
      at 3 weeks. These alterations appeared to be involved in tendon degeneration or 
      rupture after corticosteroid injection.
CI  - (c) 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
FAU - Muto, Tomoyuki
AU  - Muto T
AD  - Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 
      7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
FAU - Kokubu, Takeshi
AU  - Kokubu T
FAU - Mifune, Yutaka
AU  - Mifune Y
FAU - Inui, Atsuyuki
AU  - Inui A
FAU - Harada, Yoshifumi
AU  - Harada Y
FAU - Yoshifumi
AU  - Yoshifumi
FAU - Takase, Fumiaki
AU  - Takase F
FAU - Kuroda, Ryosuke
AU  - Kuroda R
FAU - Kurosaka, Masahiro
AU  - Kurosaka M
LA  - eng
PT  - Journal Article
DEP - 20140702
PL  - United States
TA  - J Orthop Res
JT  - Journal of orthopaedic research : official publication of the Orthopaedic 
      Research Society
JID - 8404726
RN  - 0 (Glucocorticoids)
RN  - 1ZK20VI6TY (Triamcinolone)
RN  - 9PHQ9Y1OLM (Prednisolone)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Achilles Tendon/drug effects/pathology
MH  - Animals
MH  - Apoptosis/*drug effects/genetics
MH  - Biomechanical Phenomena
MH  - Glucocorticoids/administration & dosage/*adverse effects
MH  - Injections, Intra-Articular/adverse effects
MH  - Male
MH  - Matrix Metalloproteinase 3/biosynthesis/*genetics
MH  - Prednisolone/administration & dosage/adverse effects
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rupture, Spontaneous/chemically induced/enzymology
MH  - Tendon Injuries/*chemically induced/enzymology
MH  - Triamcinolone/administration & dosage/adverse effects
OTO - NOTNLM
OT  - Achilles tendon
OT  - MMP-3
OT  - apoptosis
OT  - prednisolone
OT  - triamcinolone acetonide
EDAT- 2014/07/06 06:00
MHDA- 2014/10/08 06:00
CRDT- 2014/07/03 06:00
PHST- 2014/02/11 00:00 [received]
PHST- 2014/06/10 00:00 [accepted]
PHST- 2014/07/03 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2014/10/08 06:00 [medline]
AID - 10.1002/jor.22681 [doi]
PST - ppublish
SO  - J Orthop Res. 2014 Oct;32(10):1297-304. doi: 10.1002/jor.22681. Epub 2014 Jul 2.