PMID- 24986007
OWN - NLM
STAT- MEDLINE
DCOM- 20160310
LR  - 20211021
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 51
IP  - 3
DP  - 2015
TI  - Associations Between ApoEepsilon4 Carrier Status and Serum BDNF Levels--New Insights 
      into the Molecular Mechanism of ApoEepsilon4 Actions in Alzheimer's Disease.
PG  - 1271-7
LID - 10.1007/s12035-014-8804-8 [doi]
AB  - Insufficient neurotrophic support increases the risk for developing Alzheimer's 
      disease (AD). Mounting evidence has confirmed the association of brain-derived 
      neurotrophic factor (BDNF) and apolipoprotein E (ApoE) with AD. As both BDNF and 
      ApoE are suggested to be involved in modulating brain integrity, the present 
      study is aiming to investigate the associations between these two factors. In 
      this study, 110 AD patients and 120 cognitively normal controls (NC) were 
      recruited for measurement of serum BDNF levels and ApoE genotyping. Serum BDNF 
      levels in the AD group were significantly lower than that in the NC group, 
      reflecting insufficient neurotrophic supply in AD patients. We further found that 
      ApoE epsilon4+/- and epsilon4+/+ subjects had significantly lower serum BDNF levels than 
      epsilon4-/- subjects in the whole cohort and the NC group, suggesting altered BDNF 
      metabolism in ApoE epsilon4 carriers. Further analysis indicated possible interactions 
      between ApoEepsilon4 and BDNF in their co-effects on AD and mini-mental state 
      examination (MMSE) scores. Our findings imply that the possible involvement of 
      ApoE epsilon4 in BDNF metabolism might be another molecular mechanism underlying the 
      contribution of ApoE epsilon4 to the development of AD.
FAU - Liu, Yu-Hui
AU  - Liu YH
AD  - Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital and 
      Institute of Field Surgery, Third Military Medical University, 10 Changjiang 
      Branch Road, Yuzhong district, Chongqing, China.
FAU - Jiao, Shu-Sheng
AU  - Jiao SS
FAU - Wang, Ye-Ran
AU  - Wang YR
FAU - Bu, Xian-Le
AU  - Bu XL
FAU - Yao, Xiu-Qing
AU  - Yao XQ
FAU - Xiang, Yang
AU  - Xiang Y
FAU - Wang, Qing-Hua
AU  - Wang QH
FAU - Wang, Lin
AU  - Wang L
FAU - Deng, Juan
AU  - Deng J
FAU - Li, Jing
AU  - Li J
FAU - Zhou, Xin-Fu
AU  - Zhou XF
FAU - Zhou, Hua-Dong
AU  - Zhou HD
FAU - Wang, Yan-Jiang
AU  - Wang YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140702
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Alzheimer Disease/blood/genetics/*metabolism
MH  - Apolipoprotein E4/*metabolism
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognition/physiology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2014/07/06 06:00
MHDA- 2016/03/11 06:00
CRDT- 2014/07/03 06:00
PHST- 2014/04/23 00:00 [received]
PHST- 2014/06/22 00:00 [accepted]
PHST- 2014/07/03 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2016/03/11 06:00 [medline]
AID - 10.1007/s12035-014-8804-8 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2015;51(3):1271-7. doi: 10.1007/s12035-014-8804-8. Epub 2014 Jul 
      2.