PMID- 24987420
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140702
LR  - 20211021
IS  - 1687-9627 (Print)
IS  - 1687-9635 (Electronic)
VI  - 2014
DP  - 2014
TI  - Hemophagocytic Syndrome Associated with Immune Reconstitution Inflammatory 
      Syndrome in a Patient with AIDS Related Burkitt's Leukemia/Lymphoma.
PG  - 308081
LID - 10.1155/2014/308081 [doi]
LID - 308081
AB  - Highly active antiretroviral therapy (HAART) has markedly decreased human 
      immunodeficiency virus- (HIV-) related mortality and the incidence of 
      opportunistic infections. The dramatic reduction in HIV-1 RNA and increase in CD4 
      lymphocyte count mean a recovery in immune function. This restoration in immune 
      function may be associated with paradoxical deterioration in subclinical 
      opportunistic infections in some patients, a condition called immune 
      reconstitution inflammatory syndrome (IRIS). IRIS, a "paradoxical" inflammatory 
      response to either previously treated or subclinical infections or noninfectious 
      diseases, can manifest during the restoration phase of immunity hemophagocytic 
      syndrome (HS) which is a very rare complication in patients with acquired immune 
      deficiency syndrome (AIDS). We describe a case of hemophagocytic syndrome 
      associated with IRIS in a patient with AIDS related Burkitt's leukemia/lymphoma 
      (BL). IRIS was probably the cause of hemophagocytosis for our patient. Zoster 
      infection may facilitate to IRIS. With the increasing number of people with HIV 
      infection and the accompanying use of HAART, much more clinical manifestations of 
      IRIS will be experienced especially in patients given high dose chemotherapy, 
      just like in our case.
FAU - Kanitez, Metin
AU  - Kanitez M
AD  - Department of Medical Oncology, Sisli Education and Research Hospital, Istanbul, 
      Turkey.
FAU - Kapmaz, Mahir
AU  - Kapmaz M
AD  - Department of Clinical Microbiology and Infectious Disease, Istanbul School of 
      Medicine, Turkey.
FAU - Alpay, Nilufer
AU  - Alpay N
AD  - Department of Internal Medicine, Istanbul School of Medicine, Turkey.
FAU - Selcukbiricik, Fatih
AU  - Selcukbiricik F
AD  - Department of Medical Oncology, Sisli Education and Research Hospital, Istanbul, 
      Turkey.
FAU - Cagatay, Atahan
AU  - Cagatay A
AD  - Department of Clinical Microbiology and Infectious Disease, Istanbul School of 
      Medicine, Turkey.
FAU - Diz-Kucukkaya, Reyhan
AU  - Diz-Kucukkaya R
AD  - Department of Hematology, Istanbul Bilim University, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20140527
PL  - United States
TA  - Case Rep Med
JT  - Case reports in medicine
JID - 101512910
PMC - PMC4058513
EDAT- 2014/07/06 06:00
MHDA- 2014/07/06 06:01
PMCR- 2014/05/27
CRDT- 2014/07/03 06:00
PHST- 2014/02/07 00:00 [received]
PHST- 2014/04/20 00:00 [accepted]
PHST- 2014/07/03 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2014/07/06 06:01 [medline]
PHST- 2014/05/27 00:00 [pmc-release]
AID - 10.1155/2014/308081 [doi]
PST - ppublish
SO  - Case Rep Med. 2014;2014:308081. doi: 10.1155/2014/308081. Epub 2014 May 27.