PMID- 24987461
OWN - NLM
STAT- MEDLINE
DCOM- 20150221
LR  - 20211021
IS  - 1757-2215 (Print)
IS  - 1757-2215 (Electronic)
IS  - 1757-2215 (Linking)
VI  - 7
DP  - 2014
TI  - Positive effects of prolonged caloric restriction on the population of very small 
      embryonic-like stem cells - hematopoietic and ovarian implications.
PG  - 68
LID - 10.1186/1757-2215-7-68 [doi]
AB  - BACKGROUND: Low calorie intake, or calorie restriction (CR) without malnutrition, 
      has been demonstrated in several animal species, including mice, to increase both 
      median and maximum lifespan as well as delay reproductive senescence. Our 
      previous work demonstrated a positive correlation between life span and the 
      number of very small embryonic-like stem cells (VSELs) in long living Laron dwarf 
      mice. These animals have very low levels of circulating insulin-like growth 
      factor 1 (IGF-1) in peripheral blood (PB), maintain higher numbers of 
      hematopoietic stem cells (HSPCs) in bone marrow (BM), and display prolonged 
      fecundity compared with wild type littermates. Since CR lowers the level of IGF-1 
      in PB, we become interested in the effect of CR on the number of VSELs and HSPCs 
      in BM as well as on the morphology of ovaries and testes. METHODS: In our studies 
      four-week-old female and male mice were subjected to CR by employing an 
      alternate-day ad libitum feeding diet for a period of 9 months. RESULTS: We 
      observed that mice on CR had a higher number of BM-residing VSELs than control 
      mice fed ad libitum. These changes correlated with higher numbers of HSPCs in BM, 
      spleen, and peripheral blood (PB) as well as with an increase in the number of 
      primordial and primary follicles in ovaries. At the same time, however, no 
      changes were observed in the testes of mice under CR. CONCLUSION: We conclude 
      that CR positively affects the pool of VSELs in adult tissues and explains the 
      positive effect of CR on longevity.
FAU - Grymula, Katarzyna
AU  - Grymula K
AD  - Department of Physiology at Pomeranian, Medical University, Szczecin, Poland.
FAU - Piotrowska, Katarzyna
AU  - Piotrowska K
AD  - Department of Physiology at Pomeranian, Medical University, Szczecin, Poland.
FAU - Sluczanowska-Glabowska, Sylwia
AU  - Sluczanowska-Glabowska S
AD  - Department of Physiology at Pomeranian, Medical University, Szczecin, Poland.
FAU - Mierzejewska, Katarzyna
AU  - Mierzejewska K
AD  - Department of Physiology at Pomeranian, Medical University, Szczecin, Poland.
FAU - Tarnowski, Maciej
AU  - Tarnowski M
AD  - Department of Physiology at Pomeranian, Medical University, Szczecin, Poland.
FAU - Tkacz, Marta
AU  - Tkacz M
AD  - Department of Physiology at Pomeranian, Medical University, Szczecin, Poland.
FAU - Poniewierska-Baran, Agata
AU  - Poniewierska-Baran A
AD  - Department of Physiology at Pomeranian, Medical University, Szczecin, Poland.
FAU - Pedziwiatr, Daniel
AU  - Pedziwiatr D
AD  - Department of Physiology at Pomeranian, Medical University, Szczecin, Poland.
FAU - Suszynska, Ewa
AU  - Suszynska E
AD  - Department of Physiology at Pomeranian, Medical University, Szczecin, Poland.
FAU - Laszczynska, Maria
AU  - Laszczynska M
AD  - Department of Histology and Developmental Biology, Pomeranian Medical University, 
      Szczecin, Poland.
FAU - Ratajczak, Mariusz Z
AU  - Ratajczak MZ
AD  - Department of Physiology at Pomeranian, Medical University, Szczecin, Poland ; 
      Stem Cell Institute at the James Graham Brown Cancer Center, University of 
      Louisville, 500 S. Floyd Street, Rm. 107, Louisville, KY 40202, USA.
LA  - eng
GR  - R01 DK074720/DK/NIDDK NIH HHS/United States
GR  - 2R01 DK074720/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140621
PL  - England
TA  - J Ovarian Res
JT  - Journal of ovarian research
JID - 101474849
RN  - 0 (Biomarkers)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Blood Cell Count
MH  - Body Weight
MH  - Bone Marrow/metabolism
MH  - *Caloric Restriction
MH  - Colony-Forming Units Assay
MH  - Embryonic Stem Cells/*metabolism
MH  - Female
MH  - Gene Expression
MH  - Hematopoietic Stem Cells/*metabolism
MH  - Male
MH  - Mice
MH  - Ovary/*cytology/*metabolism
MH  - Pluripotent Stem Cells/*metabolism
MH  - Testis/metabolism
MH  - Transcription Factors/genetics/metabolism
PMC - PMC4076763
OTO - NOTNLM
OT  - Bone marrow
OT  - Calorie restriction
OT  - Longevity
OT  - Ovaries
OT  - Testes
OT  - VSELs
EDAT- 2014/07/06 06:00
MHDA- 2015/02/24 06:00
PMCR- 2014/06/21
CRDT- 2014/07/03 06:00
PHST- 2014/04/30 00:00 [received]
PHST- 2014/06/16 00:00 [accepted]
PHST- 2014/07/03 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
PHST- 2014/06/21 00:00 [pmc-release]
AID - 1757-2215-7-68 [pii]
AID - 10.1186/1757-2215-7-68 [doi]
PST - epublish
SO  - J Ovarian Res. 2014 Jun 21;7:68. doi: 10.1186/1757-2215-7-68. eCollection 2014.