PMID- 24987969
OWN - NLM
STAT- MEDLINE
DCOM- 20150206
LR  - 20140703
IS  - 0026-4733 (Print)
IS  - 0026-4733 (Linking)
VI  - 69
IP  - 4
DP  - 2014 Aug
TI  - Five-year follow-up of a prospective study comparing laparoscopic Nissen 
      fundoplication with Stretta radiofrequency for gastroesophageal reflux disease.
PG  - 217-23
AB  - AIM: Laparoscopic Nissen fundoplication (LNF) and Stretta radiofrequency (RF) are 
      used as main alternative strategies to manage medication-refractory GERD. This 
      study was therefore prospectively evaluated outcomes of patients with refractory 
      GERD 5 years after LNF or Stretta RF. METHODS: A total of 215 consecutive 
      patients with refractory GERD underwent LNF (N.=102) and Stretta RF (N.=113) in 
      our department between 2007 and 2008. They were followed-up for 5 years, during 
      which the outcome measures including symptom scores of regurgitation, heartburn, 
      chest pain, belching, hiccup, cough and asthma as well as the proton pump 
      inhibitor (PPI) use and complications. RESULTS: Of the 215 patients, 179 patients 
      following LNF (N.=87) or Stretta RF (N.=92) completed the designated 5-year 
      follow-up and were included in the final analysis. At the end of 5-year 
      follow-up, the post-treatment scores were statistically lower as compared with 
      the pre-treatment scores in both groups, while the symptom improvements after 
      Stretta were significantly lower than that after LNF (p < 0.05). Besides, 81 
      (91%) patients achieved complete PPI therapy independence after LNF, comparing 
      with 47 (51.1%) after Stretta RF (P<0.05). No significant differences in 
      post-treatment complications were observed except for the abdominal distention. 
      CONCLUSION: Even though laparoscopic Nissen fundoplication and Stretta RF are 
      capable of controlling GERD symptoms effectively and safely in selected patients, 
      LNF could improve more in symptoms and PPI elimination.
FAU - Liang, W T
AU  - Liang WT
AD  - Department of Vascular Surgery Xuanwu Hospital, Capital Medical University 
      Xicheng District, Beijing, P. R. China - zhonggaowang@hotmail.com.
FAU - Wu, J N
AU  - Wu JN
FAU - Wang, F
AU  - Wang F
FAU - Hu, Z W
AU  - Hu ZW
FAU - Wang, Z G
AU  - Wang ZG
FAU - Ji, T
AU  - Ji T
FAU - Zhan, X L
AU  - Zhan XL
FAU - Zhang, C
AU  - Zhang C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PL  - Italy
TA  - Minerva Chir
JT  - Minerva chirurgica
JID - 0400726
SB  - IM
MH  - Adult
MH  - *Catheter Ablation/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Fundoplication/*methods
MH  - Gastroesophageal Reflux/*surgery
MH  - Humans
MH  - *Laparoscopy/methods
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2014/07/06 06:00
MHDA- 2015/02/07 06:00
CRDT- 2014/07/03 06:00
PHST- 2014/07/03 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/02/07 06:00 [medline]
AID - R06Y2014N04A0217 [pii]
PST - ppublish
SO  - Minerva Chir. 2014 Aug;69(4):217-23.