PMID- 24988873
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20140718
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 49
IP  - 8
DP  - 2014 Aug
TI  - A comparison between 15-day sequential, 10-day sequential and proton pump 
      inhibitor-based triple therapy for Helicobacter pylori infection in Korea.
PG  - 917-24
LID - 10.3109/00365521.2014.896409 [doi]
AB  - OBJECTIVE: The eradication rate of 10-day sequential therapy for Helicobacter 
      pylori (H. pylori) infection was not satisfactory in Korea, probably due to 
      antibiotic resistance. To compare the treatment efficacy of 15-day and 10-day 
      sequential therapy of conventional 7-day proton pump inhibitor (PPI) triple 
      therapy for the treatment of H. pylori infection. METHODS: A total of 332 
      patients with H. pylori infection were randomly assigned to receive either 7-day 
      PPI triple therapy, 10-day sequential therapy or 15-day sequential therapy. 
      Eradication rate, drug compliance, and adverse events were compared among the 
      three regimens. RESULTS: The eradication rates by intention-to-treat analysis 
      were 64.3% (95% CI: 55.5-73.2; 74 of 115 patients), 72.1% (95% CI: 63.6-80.5; 80 
      of 111 patients), and 80.2% (95% CI: 72.5-87.9; 85 of 106 patients) in the 7-day 
      PPI triple, 10-day and 15-day sequential therapy groups, respectively (p = 
      0.032). The eradication rates by per-protocol analysis were 68.5% (95% CI: 
      59.6-77.4; 74 of 108 patients), 78.4% (95% CI: 70.3-86.5; 80 of 102 patients), 
      and 89.5% (95% CI: 83.2-95.8; 85 of 95 patients) in the 7-day PPI triple, 10-day 
      and 15-day sequential therapy groups, respectively (p = 0.001). There were no 
      statistically significant differences between the three eradication therapy 
      groups in regard to drug compliance and adverse events. CONCLUSION: The 15-day 
      sequential therapy demonstrated improved eradication efficacy compared with 7-day 
      PPI triple and 10-day sequential therapy in Korea.
FAU - Lee, Jung Won
AU  - Lee JW
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital , 
      Seongnam, Gyeonggi-do , Korea.
FAU - Kim, Nayoung
AU  - Kim N
FAU - Kim, Jung Mogg
AU  - Kim JM
FAU - Nam, Ryoung Hee
AU  - Nam RH
FAU - Kim, Jae Yeon
AU  - Kim JY
FAU - Lee, Ju Yup
AU  - Lee JY
FAU - Lee, Dong Ho
AU  - Lee DH
FAU - Jung, Hyun Chae
AU  - Jung HC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140703
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - 140QMO216E (Metronidazole)
RN  - 804826J2HU (Amoxicillin)
RN  - H1250JIK0A (Clarithromycin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amoxicillin/*therapeutic use
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Anti-Infective Agents/*therapeutic use
MH  - Breath Tests
MH  - Clarithromycin/*therapeutic use
MH  - Drug Administration Schedule
MH  - Drug Therapy, Combination
MH  - Female
MH  - Follow-Up Studies
MH  - Helicobacter Infections/*drug therapy
MH  - Humans
MH  - Male
MH  - Metronidazole/*therapeutic use
MH  - Middle Aged
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Republic of Korea
MH  - Treatment Outcome
OTO - NOTNLM
OT  - 15-day sequential
OT  - Helicobacter pylori
OT  - eradication
OT  - resistance
EDAT- 2014/07/06 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/07/04 06:00
PHST- 2014/07/04 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - 10.3109/00365521.2014.896409 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2014 Aug;49(8):917-24. doi: 10.3109/00365521.2014.896409. 
      Epub 2014 Jul 3.