PMID- 24989023
OWN - NLM
STAT- MEDLINE
DCOM- 20141212
LR  - 20151119
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 67
IP  - 9
DP  - 2014 Sep
TI  - IgE deficiency may indicate underlying hypogammaglobulinaemia?
PG  - 832-3
AB  - Low serum immunoglobulin E (IgE) (<2 kU/L) found during allergy investigations 
      may be a marker for other immunodeficiency states, in particular common variable 
      immunodeficiency. The latter is characterised by recurrent infections, mainly 
      respiratory, resulting in structural lung damage making early diagnosis 
      important. We looked through 4013 samples retrospectively over a 12-month period 
      to identify samples with IgE<2 kU/L. We identified 74/4013 (1.84%) with serum IgE 
      levels<2 kU/L. Only 20 samples had serum immunoglobulin quantification and serum 
      electrophoresis requested. Three of these samples were from the same patient, 
      10/18 (56%) had one or more classes of immunoglobulin above/below reference range 
      for age and two of these had new diagnosis of immunodeficiency. Serum IgE<2 kU/L 
      can be a marker for hypogammaglobulinaemia or common variable immunodeficiency. 
      As early diagnosis is important to reduce morbidity and mortality, very low serum 
      IgE should trigger further investigation-that is, serum protein electrophoresis 
      and immunoglobulin quantification.
FAU - McVicker, Shireen
AU  - McVicker S
FAU - Karim, M Yousuf
AU  - Karim MY
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Agammaglobulinemia/blood/*diagnosis/immunology
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood/*deficiency
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
EDAT- 2014/07/06 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/07/04 06:00
PHST- 2014/07/04 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - jclinpath-2014-202461 [pii]
AID - 10.1136/jclinpath-2014-202461 [doi]
PST - ppublish
SO  - J Clin Pathol. 2014 Sep;67(9):832-3. doi: 10.1136/jclinpath-2014-202461.