PMID- 24989292 OWN - NLM STAT- MEDLINE DCOM- 20141211 LR - 20181023 IS - 1009-2137 (Print) IS - 1009-2137 (Linking) VI - 22 IP - 3 DP - 2014 Jun TI - [Clinical study of unrelated umbilical cord blood transplantation for 25 patients with hematological diseases]. PG - 767-73 LID - 10.7534/j.issn.1009-2137.2014.03.036 [doi] AB - This study was purposed to investigate the engraftment, graft-versus-host disease (GVHD), transplantation related mortality (TRM), relapse and survival in hematologic patients received unrelated umbilical cord blood transplantation (UCBT). A total of 25 patients with hematological disease underwent UCBT, including 8 pediatric and 17 young adult patients. Among them 3 cases received single unit of UCBT and 22 cases received double units of UCBT. For donor/recipients human leukocyte antigen (HLA) matching: HLA 6/6 loci matched in 9 cases, HLA 4-5/6 loci matched in 16 cases. There were 19 patients with hematologic malignancies, including 3 cases in the period of disease progression and 6 cases of non-hematologic malignancies. Conditioning regimens were TBI/Cy +/- Flu +/- ATG or BuCy +/- Flu +/- ATG for 21 patients and Cy+Flu+ATG for 4 patients. For prophylaxis of acute graft-versus-host disease (aGVHD) the regimen of cyclosporine (CsA) as dominant drug was used. The results showed that among 16 patients (80.0%) achieved engraftment, 20 patients survived for more than 42 d after transplantation. The cumulative neutrophil recovery rate on day 42 after transplant was 64.0%, with a median time of 17.0 d;the cumulative platelet recovery rate on day 100 after transplant was 60.0 %, with a median time of 35.0 d. The cumulative rate of grade II-IV and III-IV aGVHD after transplantation 100 d was 44.0% and 30.7%, respectively. Until the end of the follow-up, the cumulative rate of TRM was 54.3%. For all the patients, overall survival rate was 42.7%. Out of 17 evaluable patients with hematologic malignancies 7 cases (41.2%) survived to date, and only 1 case relapsed, so event-free survival rate was 35.3%. Out of 5 evaluable patients with non-hematologic malignancies, 4 patients survived and 2 patients were in stable engraftment state, 2 cases with autologous hematopoietic recovery. Among 3 cases of hematologic malignancies at advanced stage, only 1 case survived to date. It is concluded that HLA-4-6/6 loci matched UCBT is an effective option to treat hematological diseases. Double cord blood transplantation (dUCBT) can overcome the disadvantage of insufficient cells of single cord blood UCBT to treat overweight children and adult. FAU - Chang, Hui-Rong AU - Chang HR AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. FAU - Cheng, Zhen AU - Cheng Z AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. FAU - Chen, Guang-Hua AU - Chen GH AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. FAU - Sun, Ai-Ning AU - Sun AN AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. E-mail: ainingsun@hotmail.com. FAU - Qiao, Man AU - Qiao M AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. FAU - Ma, Xiao AU - Ma X AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. FAU - Wang, Ying AU - Wang Y AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. FAU - Chen, Feng AU - Chen F AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. FAU - Jin, Huan-Ying AU - Jin HY AD - Shanghai Cord Blood Bank, Shanghai 200051, China. FAU - Lu, Yao AU - Lu Y AD - Shanghai Cord Blood Bank, Shanghai 200051, China. FAU - Zhang, Jia-Qing AU - Zhang JQ AD - Shanghai Cord Blood Bank, Shanghai 200051, China. FAU - Fu, Cheng-Cheng AU - Fu CC AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. FAU - Jin, Zheng-Min AU - Jin ZM AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. FAU - Tang, Xiao-Wen AU - Tang XW AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. FAU - Han, Ye AU - Han Y AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. FAU - Qiu, Hui-Ying AU - Qiu HY AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. FAU - Wu, De-Pei AU - Wu DP AD - Jiangsu Institute of Hematology, Key laboratory of Thrombosis and Hemostasis, Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China. LA - chi PT - English Abstract PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - China TA - Zhongguo Shi Yan Xue Ye Xue Za Zhi JT - Zhongguo shi yan xue ye xue za zhi JID - 101084424 SB - IM MH - Adolescent MH - Adult MH - Child MH - Child, Preschool MH - Cord Blood Stem Cell Transplantation/*methods MH - Female MH - Fetal Blood MH - Graft vs Host Disease MH - Hematologic Diseases/*therapy MH - Histocompatibility Testing MH - Humans MH - Male MH - Survival Rate MH - Young Adult EDAT- 2014/07/06 06:00 MHDA- 2014/12/17 06:00 CRDT- 2014/07/04 06:00 PHST- 2014/07/04 06:00 [entrez] PHST- 2014/07/06 06:00 [pubmed] PHST- 2014/12/17 06:00 [medline] AID - 1009-2137(2014)03-0767-07 [pii] AID - 10.7534/j.issn.1009-2137.2014.03.036 [doi] PST - ppublish SO - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Jun;22(3):767-73. doi: 10.7534/j.issn.1009-2137.2014.03.036.