PMID- 24989395
OWN - NLM
STAT- MEDLINE
DCOM- 20150224
LR  - 20220311
IS  - 2473-4209 (Electronic)
IS  - 0094-2405 (Print)
IS  - 0094-2405 (Linking)
VI  - 41
IP  - 7
DP  - 2014 Jul
TI  - Size-specific dose estimate (SSDE) provides a simple method to calculate organ 
      dose for pediatric CT examinations.
PG  - 071917
LID - 10.1118/1.4884227 [doi]
LID - 071917
AB  - PURPOSE: To investigate the correlation of size-specific dose estimate (SSDE) 
      with absorbed organ dose, and to develop a simple methodology for estimating 
      patient organ dose in a pediatric population (5-55 kg). METHODS: Four physical 
      anthropomorphic phantoms representing a range of pediatric body habitus were 
      scanned with metal oxide semiconductor field effect transistor (MOSFET) 
      dosimeters placed at 23 organ locations to determine absolute organ dose. Phantom 
      absolute organ dose was divided by phantom SSDE to determine correlation between 
      organ dose and SSDE. Organ dose correlation factors (CF(organ)(SSDE)) were then 
      multiplied by patient-specific SSDE to estimate patient organ dose. The 
      [CF(organ)(SSDE)) were used to retrospectively estimate individual organ doses 
      from 352 chest and 241 abdominopelvic pediatric CT examinations, where mean 
      patient weight was 22 kg +/- 15 (range 5-55 kg), and mean patient age was 6 yrs +/- 5 
      (range 4 months to 23 yrs). Patient organ dose estimates were compared to 
      published pediatric Monte Carlo study results. RESULTS: Phantom effective 
      diameters were matched with patient population effective diameters to within 4 
      cm; thus, showing appropriate scalability of the phantoms across the entire 
      pediatric population in this study. Individual CF(organ)(SSDE) were determined 
      for a total of 23 organs in the chest and abdominopelvic region across nine 
      weight subcategories. For organs fully covered by the scan volume, correlation in 
      the chest (average 1.1; range 0.7-1.4) and abdominopelvic region (average 0.9; 
      range 0.7-1.3) was near unity. For organ/tissue that extended beyond the scan 
      volume (i.e., skin, bone marrow, and bone surface), correlation was determined to 
      be poor (average 0.3; range: 0.1-0.4) for both the chest and abdominopelvic 
      regions, respectively. A means to estimate patient organ dose was demonstrated. 
      Calculated patient organ dose, using patient SSDE and CF(organ)(SSDE), was 
      compared to previously published pediatric patient doses that accounted for 
      patient size in their dose calculation, and was found to agree in the chest to 
      better than an average of 5% (27.6/26.2) and in the abdominopelvic region to 
      better than 2% (73.4/75.0). CONCLUSIONS: For organs fully covered within the scan 
      volume, the average correlation of SSDE and organ absolute dose was found to be 
      better than +/- 10%. In addition, this study provides a complete list of organ dose 
      correlation factors (CF(organ)(SSDE)) for the chest and abdominopelvic regions, 
      and describes a simple methodology to estimate individual pediatric patient organ 
      dose based on patient SSDE.
FAU - Moore, Bria M
AU  - Moore BM
AD  - Department of Radiological Sciences, St Jude Children's Research Hospital, 
      Memphis, Tennessee 38105.
FAU - Brady, Samuel L
AU  - Brady SL
AD  - Department of Radiological Sciences, St Jude Children's Research Hospital, 
      Memphis, Tennessee 38105.
FAU - Mirro, Amy E
AU  - Mirro AE
AD  - Department of Biomedical Engineering, Washington University, St Louis, Missouri 
      63130.
FAU - Kaufman, Robert A
AU  - Kaufman RA
AD  - Department of Radiological Sciences, St Jude Children's Research Hospital, 
      Memphis, Tennessee 38105.
LA  - eng
GR  - R25 CA023944/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
SB  - IM
MH  - Adolescent
MH  - Body Weight
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Models, Biological
MH  - Monte Carlo Method
MH  - Pelvis/diagnostic imaging
MH  - Phantoms, Imaging
MH  - *Radiation Dosage
MH  - Radiography, Abdominal/instrumentation/methods
MH  - Radiography, Thoracic/instrumentation/methods
MH  - Radiometry
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/instrumentation/*methods
MH  - Young Adult
PMC - PMC5148074
EDAT- 2014/07/06 06:00
MHDA- 2015/02/25 06:00
PMCR- 2015/07/01
CRDT- 2014/07/04 06:00
PHST- 2014/07/04 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/02/25 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - 052407MPH [pii]
AID - 1.4884227 [pii]
AID - 10.1118/1.4884227 [doi]
PST - ppublish
SO  - Med Phys. 2014 Jul;41(7):071917. doi: 10.1118/1.4884227.