PMID- 24989685
OWN - NLM
STAT- MEDLINE
DCOM- 20150701
LR  - 20161125
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 40
IP  - 6
DP  - 2014 Dec
TI  - Assessment of myocardial partition coefficient of gadolinium (lambda) in dilated 
      cardiomyopathy and its impact on segmental and global systolic function.
PG  - 1336-41
LID - 10.1002/jmri.24515 [doi]
AB  - PURPOSE: 1) To assess the myocardial partition coefficient (lambda) of gadolinium 
      quantified using T1 mapping in dilated cardiomyopathy (DCM); and 2) to assess the 
      impact of increased lambda on left ventricular (LV) circumferential strain and 
      ejection fraction in DCM. MATERIALS AND METHODS: Seventeen patients with DCM and 
      11 controls were prospectively included. All patients and controls underwent a 
      1.5 T MRI using: 1) cine to quantify LV volumes and function; 2) tagging to 
      quantify circumferential strain in mid-LV; 3) T1 mapping before and 9 minutes 
      after contrast injection to quantify R1, DeltaR1, and lambda; and 4) inversion recovery 3D 
      Flash was used to assess late gadolinium enhancement (LGE) 10 minutes after Gd 
      DOTA injection (0.2 mmol/kg). We used Student's t-test to compare means, 
      Pearson's test for correlation assessment, and a mixed linear model to integrate 
      the dependency between myocardial segments. RESULTS: No difference in median lambda 
      was measured between patients with (0.52 [interquartile range = 0.48-0.56]) and 
      without enhancement on LGE (0.51 [0.47-0.54]; P = 0.07). Circumferential strain 
      value measured in each segment was correlated with the lambda measured in the 
      corresponding segment (r = 0.55; P < 0.0001). Multivariate analysis revealed a 
      significant link between the lambda in each segment and circumferential strain (0.002 
      +/- 0.001; P = 0.009) and also with ejection fraction (-0.001 +/- 0.0008; P = 0.04). 
      CONCLUSION: In DCM, lambda correlates independently with circumferential strain and 
      ejection fraction, suggesting that there is a link between lambda and systolic 
      function.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Jacquier, Alexis
AU  - Jacquier A
AD  - Department of Radiology, Aix Marseille Universite, Hopital Universitaire la 
      Timone, Marseille, France; Centre de Resonance Magnetique Biologique et Medicale 
      (CRMBM), UMR CNRS n degrees  6612, Aix Marseille Universite, Faculte de Medecine de 
      Marseille, Marseille, France.
FAU - Kallifatidis, Alexandros
AU  - Kallifatidis A
FAU - Guibert, Nicolas
AU  - Guibert N
FAU - Giorgi, Roch
AU  - Giorgi R
FAU - Falque, Claire
AU  - Falque C
FAU - Thuny, Franck
AU  - Thuny F
FAU - Croisille, Pierre
AU  - Croisille P
FAU - Clarysse, Patrick
AU  - Clarysse P
FAU - Maurel, Boris
AU  - Maurel B
FAU - Flavian, Antonin
AU  - Flavian A
FAU - Gaubert, Jean-Yves
AU  - Gaubert JY
FAU - Moulin, Guy
AU  - Moulin G
FAU - Habib, Gilbert
AU  - Habib G
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20131125
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 6HG8UB2MUY (Meglumine)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
MH  - Aged
MH  - Cardiomyopathy, Dilated/complications/*diagnosis/*metabolism
MH  - Compressive Strength
MH  - Computer Simulation
MH  - Contrast Media/pharmacokinetics
MH  - Elastic Modulus
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Male
MH  - Meglumine/*pharmacokinetics
MH  - Metabolic Clearance Rate
MH  - Middle Aged
MH  - *Models, Cardiovascular
MH  - Organometallic Compounds/*pharmacokinetics
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Stress, Mechanical
MH  - Stroke Volume
MH  - Tensile Strength
MH  - Tissue Distribution
MH  - Ventricular Dysfunction, Left/diagnosis/*etiology/*metabolism
OTO - NOTNLM
OT  - MRI
OT  - contrast media
OT  - dilated cardiomyopathy
OT  - fibrosis
OT  - myocardium
EDAT- 2014/07/06 06:00
MHDA- 2015/07/02 06:00
CRDT- 2014/07/04 06:00
PHST- 2013/07/31 00:00 [received]
PHST- 2013/10/03 00:00 [accepted]
PHST- 2014/07/04 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/07/02 06:00 [medline]
AID - 10.1002/jmri.24515 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2014 Dec;40(6):1336-41. doi: 10.1002/jmri.24515. Epub 2013 
      Nov 25.